Epithelial homeostasis and tumorigenesis

Chloé FÉRAL, Research Director, DR2 Inserm
  • Cyclic uniaxial cell stretching in tissue culture using a LEGO®-based mechanical stretcher and a polydimethylsiloxane stretchable vessel.

    Boulter E*, Féral CC* (*co-corresponding).

    STAR Protoc. 2021 Apr 8;2(2):100437. doi: 10.1016/j.xpro.2021.100437. eCollection 2021 Jun 18.

    PMID: 33899018

  • A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy

    Douguet L, Janho Dit Hreich S, Benzaquen J, Seguin L, Juhel T, Dezitter X, Duranton C, Ryffel B, Kanellopoulos J, Delarasse C, Renault N, Furman C, Homerin G, Féral C, Cherfils-Vicini J, Millet R, Adriouch S, Ghinet A, Hofman P, Vouret-Craviari V.

    Nat Commun. 2021 Jan 28;12(1):653. doi: 10.1038/s41467-021-20912-2.

    PMID: 33510147

  • Cyclic uniaxial mechanical stretching of cells using a LEGO ® parts-based mechanical stretcher system
    Boulter E, Tissot FS, Dilly J, Pisano S, Féral CC.
    J Cell Sci. 2020 Jan 6;133(1):jcs234666. doi: 10.1242/jcs.234666.
  • Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.

    Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C.

    Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012. Epub 2018 Oct 4.

    PMID 30293773

  • Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states.

    Andersen MS, Hannezo E, Ulyanchenko S, Estrach S, Antoku Y, Pisano S, Boonekamp KE, Sendrup S, Maimets M, Pedersen MT, Johansen JV, Clement DL, Feral CC, Simons BD, Jensen KB.

    Nat Cell Biol. 2019 Aug;21(8):924-932. doi: 10.1038/s41556-019-0362-x. Epub 2019 Jul 29.

    PMID: 31358966
  • Dermal Fibroblast SLC3A2 Deficiency Leads to Premature Aging and Loss of Epithelial Homeostasis

    J Invest Dermatol. 2018 Dec;138(12):2511-2521. doi: 10.1016/j.jid.2018.05.026. Epub 2018 Jun 12.

    PMID: 29906411
  • Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway

    Nat Commun. 2018 Nov 19;9(1):4862. doi: 10.1038/s41467-018-07268-w.

    PMID: 30451822
  • 18F-fluorodihydroxyphenylalanine PET/CT in pheochromocytoma and paraganglioma: relation to genotype and amino acid transport system L.

    Feral CC, Tissot FS, Tosello L, Fakhry N, Sebag F, Pacak K, Taïeb D.

    Eur J Nucl Med Mol Imaging. 2017 May;44(5):812-821

    PMID: 27900521
  • Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability

    J Biol Chem. 2016 Apr 29;291(18):9700-11. doi: 10.1074/jbc.M115.704254. Epub 2016 Mar 5.

    PMID: 26945935
  • The body's tailored suit: Skin as a mechanical interface

    Tissot FS, Boulter E, Estrach S, Féral CC.

    Eur J Cell Biol. 2016 Nov;95(11):475-482.

    PMID: 27461124

  • Brucella Intracellular Life Relies on the Transmembrane Protein CD98 Heavy Chain

    Keriel A, Botella E, Estrach S, Bragagnolo G, Vergunst AC, Feral CC, O'Callaghan D.

    J Infect Dis. 2015 Jun 1;211(11):1769-78. doi: 10.1093/infdis/jiu673. Epub 2014 Dec 11.


  • CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction.

    Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg MH, Féral CC.

    Cancer Res. 2014 Dec 1;74(23):6878-89. doi: 10.1158/0008-5472.CAN-14-0579. Epub 2014 Sep 29.


  • CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

    Boulter E, Estrach S, Errante A, Pons C, Cailleteau L, Tissot F, Meneguzzi G, Féral CC.

    J Exp Med. 2013 Jan 14;210(1):173-90. doi: 10.1084/jem.20121651. Epub 2013 Jan 7.


  • Off the beaten paths: alternative and crosstalk regulation of Rho GTPases

    Boulter E, Estrach S, Garcia-Mata R, Féral CC.

    FASEB J. 2012 Feb;26(2):469-79. doi: 10.1096/fj.11-192252. Epub 2011 Oct 28. Review.


  • Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice

    Mothe-Satney I, Filloux C, Amghar H, Pons C, Bourlier V, Galitzky J, Grimaldi PA, Féral CC, Bouloumié A, Van Obberghen E, Neels JG.

    Diabetes. 2012 Sep;61(9):2311-9. doi: 10.2337/db11-1455. Epub 2012 Jun 11.


Les équipes de recherche