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Flip-flop genomics: Charting inversions in the human population.
Lanciano S, Cristofari G.
Cell. 2022 May 26;185(11):1811-1813. doi: 10.1016/j.cell.2022.05.002
PMID: 35623326
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Locus-specific chromatin profiling of evolutionarily young transposable elements
Taylor D, Lowe R, Philippe C, Cheng KCL, Grant OA, Zabet NR, Cristofari G, Branco MR.
Nucleic Acids Res. 2022 Apr 8;50(6):e33. doi: 10.1093/nar/gkab1232
PMID: 34908129
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TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.
Matkovic R, Morel M, Lanciano S, Larrous P, Martin B, Bejjani F, Vauthier V, Hansen MMK, Emiliani S, Cristofari G, Gallois-Montbrun S, Margottin-Goguet F.
Nat Commun. 2022 Jan 10;13(1):66. doi: 10.1038/s41467-021-27650-5
PMID: 35013187
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Nascent RNA m6A modification at the heart of the gene-retrotransposon conflict
Billon V, Cristofari G.
Cell Res. 2021 Aug;31(8):829-831. doi: 10.1038/s41422-021-00518-5
PMID: 34108664
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Measuring and interpreting transposable element expression.
Lanciano S, Cristofari G.
Nat Rev Genet. 2020 Dec;21(12):721-736. doi: 10.1038/s41576-020-0251-y
PMID: 32576954
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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition.
Tristán-Ramos P, Rubio-Roldan A, Peris G, Sánchez L, Amador-Cubero S, Viollet S, Cristofari G, Heras SR.
Nat Commun. 2020 Nov 11;11(1):5712. doi: 10.1038/s41467-020-19430-4
PMID: 33177501
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The landscape of L1 retrotransposons in the human genome is shaped by pre-insertion sequence biases and post-insertion selection.
Sultana T*, van Essen D*, Siol O, Bailly-Bechet M, Philippe C, Zine El Aabidine A, Pioger L, Nigumann P, Saccani S, Andrau JC, Gilbert N, Cristofari G. [*co-first authors]
Mol Cell. 2019 May 2;74(3):555-570.e7. doi: 10.1016/j.molcel.2019.02.036
PMID: 30956044
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FSHD1 and FSHD2 form a disease continuum.
Sacconi S, Briand-Suleau A, Gros M, Baudoin C, Lemmers RJLF, Rondeau S, Lagha N, Nigumann P, Cambieri C, Puma A, Chapon F, Stojkovic T, Vial C, Bouhour F, Cao M, Pegoraro E, Petiot P, Behin A, Marc B, Eymard B, Echaniz-Laguna A, Laforet P, Salviati L, Jeanpierre M, Cristofari G*, van der Maarel SM*. [*co-last authors]
Neurology. 2019 May 7;92(19):e2273-e2285. doi: 10.1212/WNL.0000000000007456
PMID: 30979860
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The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again.
Hofman P, Ayache N, Barbry P, Barlaud M, Bel A, Blancou P, Checler F, Chevillard S, Cristofari G, Demory M, Esnault V, Falandry C, Gilson E, Guérin O, Glaichenhaus N, Guigay J, Ilié M, Mari B, Marquette CH, Paquis-Flucklinger V, Prate F, Saintigny P, Seitz-Polsky B, Skhiri T, Van Obberghen-Schilling E, Van Obberghen E, Yvan-Charvet L.
Cancers (Basel). 2019 Feb 21;11(2):250. doi: 10.3390/cancers11020250
PMID: 30795607
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Inflammatory facioscapulohumeral muscular dystrophy type 2 in 18p deletion syndrome.
Renard D, Taieb G, Garibaldi M, Maues De Paula A, Bernard R, Lagha N, Cristofari G, Vovan C, Chaix C, Lévy N, Khau Van Kien P, Sacconi S.
Am J Med Genet A. 2018 Aug;176(8):1760-1763.
- PMID: 30055030
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HIV-1 Vpr and p21 restrict LINE-1 mobility.
Kawano K, Doucet AJ, Ueno M, Kariya R, An W, Marzetta F, Kuroki M, Turelli P, Sukegawa S, Okada S, Strebel K, Trono D, Ariumi Y.
Nucleic Acids Res. 2018 Sep 19;46(16):8454-8470.
- PMID: 30085096
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Meningeal SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily B member 1 (SMARCB1)-deficient tumours: an emerging group of meningeal tumours.
Dadone B, Fontaine D, Mondot L, Cristofari G, Jouvet A, Godfraind C, Varlet P, Ranchère-Vince D, Coindre JM, Gastaud L, Baudoin C, Peyron AC, Thyss A, Coutts M, Michiels JF, Pedeutour F, Burel-Vandenbos F; RENOP.
Neuropathol Appl Neurobiol. 2017 Aug;43(5):433-449.
- PMID: 27732747
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Human Retrotransposons in Health and Disease
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Integration site selection by retroviruses and transposable elements in eukaryotes.
Sultana T*, Zamborlini A*, Cristofari G@, Lesage P@
Nat Rev Genet. 2017 May;18(5):292-308.
- PMID: 28286338
*co-first authors, @co-last authors
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International Congress on Transposable elements (ICTE 2016) in Saint Malo: mobile elements under the sun of Brittany.
Lesage P, Bétermier M, Bridier-Nahmias A, Chandler M, Chambeyron S, Cristofari G, Gilbert N, Quesneville H, Vaury C, Volff JN.
Mob DNA. 2016 Oct 20;7:19. Meeting Report.
- PMID: 30044887
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Virus-derived DNA drives mosquito vector tolerance to arboviral infection.
Goic B, Stapleford KA, Frangeul L, Doucet AJ, Gausson V, Blanc H, Schemmel-Jofre N, Cristofari G, Lambrechts L, Vignuzzi M, Saleh MC.
Nat Commun. 2016 Sep 1;7:12410.
PMID: 27580708
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Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci.
Philippe C, Vargas-Landin DB, Doucet AJ, van Essen D, Vera-Otarola J, Kuciak M, Corbin A, Nigumann P, Cristofari G.
Elife. 2016 Mar 26;5. pii: e13926
- PMID: 27016617
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Post-Transcriptional Control of LINE-1 Retrotransposition by Cellular Host Factors in Somatic Cells.
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Biochemical Approaches to Study LINE-1 Reverse Transcriptase Activity In Vitro.
Viollet S, Doucet AJ, Cristofari G.
Methods Mol Biol. 2016;1400:357-76.
- PMID: 26895064
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Virus-derived DNA drives mosquito vector tolerance to arboviral infection
Goic B, Stapleford KA, Frangeul L, Doucet AJ, Gausson V, Blanc H, Schemmel-Jofre N, Cristofari G, Lambrechts L, Vignuzzi M, Saleh MC.
Nat Commun. 2016 Sep 1;7:12410.
PMID:27580708
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Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts.
Albrengues J, Bertero T, Grasset E, Bonan S, Maiel M, Bourget I, Philippe C, Herraiz Serrano C, Benamar S, Croce O, Sanz-Moreno V, Meneguzzi G, Feral CC, Cristofari G, Gaggioli C.
Nat Commun. 2015 Dec 15;6:10204.
- PMID: 26667266
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Dismantling papillary renal cell carcinoma classification: The heterogeneity of genetic profiles suggests several independent diseases.
Marsaud A, Dadone B, Ambrosetti D, Baudoin C, Chamorey E, Rouleau E, Lefol C, Roussel JF, Fabas T, Cristofari G, Carpentier X, Michiels JF, Amiel J, Pedeutour F.
Genes Chromosomes Cancer. 2015 Jun;54(6):369-82.
- PMID: 25820192
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euL1db: the European database of L1HS retrotransposon insertions in humans.
Mir AA, Philippe C, Cristofari G.
Nucleic Acids Res. 2015 Jan;43(Database issue):D43-7.
- PMID: 25352549
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L1 retrotransposition: The snap-velcro model and its consequences.
Viollet S, Monot C, Cristofari G.
Mob Genet Elements. 2014 Jan 1;4(1):e28907. Review.
- PMID: 24818067
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The specificity and flexibility of L1 reverse transcription priming at imperfect T-tracts.
Monot C, Kuciak M, Viollet S, Mir AA, Gabus C, Darlix JL, Cristofari G.
PLoS Genet. 2013 May;9(5):e1003499.
- PMID: 23675310
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RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila.
Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Gausson V, Vera-Otarola J, Cristofari G, Saleh MC.
Nat Immunol. 2013 Apr;14(4):396-403.
- PMID: 23435119
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Structure of active dimeric human telomerase.
Sauerwald A, Sandin S, Cristofari G, Scheres SH, Lingner J, Rhodes D.
Nat Struct Mol Biol. 2013 Apr;20(4):454-60.
PMID: 23474713
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A single zinc finger optimizes the DNA interactions of the nucleocapsid protein of the yeast retrotransposon Ty3.
Chaurasiya KR, Geertsema H, Cristofari G, Darlix JL, Williams MC.
Nucleic Acids Res. 2012 Jan;40(2):751-60.
- PMID: 21917850
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The catalytic and the RNA subunits of human telomerase are required to immortalize equid primary fibroblasts.
Vidale P, Magnani E, Nergadze SG, Santagostino M, Cristofari G, Smirnova A, Mondello C, Giulotto E.
Chromosoma. 2012 Oct;121(5):475-88.
- PMID: 22797876
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International Congress on Transposable Elements (ICTE) 2012 in Saint Malo and the sea of TE stories.
Ainouche A, Bétermier M, Chandler M, Cordaux R, Cristofari G, Deragon JM, Lesage P, Panaud O, Quesneville H, Vaury C, Vieira C, Vitte C.
Mob DNA. 2012 Oct 30;3(1):17. Meeting Report.
- PMID: 23110759
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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo.
Abreu E, Aritonovska E, Reichenbach P, Cristofari G, Culp B, Terns RM, Lingner J, Terns MP.
Mol Cell Biol. 2010 Jun;30(12):2971-82.
PMID: 20404094
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An affinity oligonucleotide displacement strategy to purify ribonucleoprotein complexes applied to human telomerase.
Kurth I, Cristofari G, Lingner J.
Methods Mol Biol. 2008;488:9-22.
- PMID: 18982281
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Telomerase unplugged.
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Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.
De Cian A, Cristofari G, Reichenbach P, De Lemos E, Monchaud D, Teulade-Fichou MP, Shin-Ya K, Lacroix L, Lingner J, Mergny JL.
Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17347-52.
- PMID: 17954919
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Low- to high-throughput analysis of telomerase modulators with Telospot.
Cristofari G, Reichenbach P, Regamey PO, Banfi D, Chambon M, Turcatti G, Lingner J.
Nat Methods. 2007 Oct;4(10):851-3.
- PMID: 17893679
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Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation.
Cristofari G, Adolf E, Reichenbach P, Sikora K, Terns RM, Terns MP, Lingner J.
Mol Cell. 2007 Sep 21;27(6):882-9.
- PMID: 17889662
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Telomere length homeostasis requires that telomerase levels are limiting.
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The hepatitis C virus Core protein is a potent nucleic acid chaperone that directs dimerization of the viral (+) strand RNA in vitro.
Cristofari G, Ivanyi-Nagy R, Gabus C, Boulant S, Lavergne JP, Penin F, Darlix JL.
Nucleic Acids Res. 2004 May 11;32(8):2623-31.
PMID: 15141033
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Fingering the ends: how to make new telomeres.
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The ubiquitous nature of RNA chaperone proteins.
Cristofari G, Darlix JL.
Prog Nucleic Acid Res Mol Biol. 2002;72:223-68. Review.
- PMID: 12206453
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A 5'-3' long-range interaction in Ty1 RNA controls its reverse transcription and retrotransposition.
Cristofari G, Bampi C, Wilhelm M, Wilhelm FX, Darlix JL.
EMBO J. 2002 Aug 15;21(16):4368-79.
- PMID: 12169639
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Nucleocapsid protein of human immunodeficiency virus as a model protein with chaperoning functions and as a target for antiviral drugs.
Darlix JL, Cristofari G, Rau M, Péchoux C, Berthoux L, Roques B.
Adv Pharmacol. 2000;48:345-72. Review.
- PMID: 10987096
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The GAG-like protein of the yeast Ty1 retrotransposon contains a nucleic acid chaperone domain analogous to retroviral nucleocapsid proteins.
Cristofari G, Ficheux D, Darlix JL.
J Biol Chem. 2000 Jun 23;275(25):19210-7.
- PMID: 10766747
