Transcription Specificity

Simona SACCANI, Research Director, DR2 Inserm
  • Role of cell-type specific nucleosome positioning in inducible activation of mammalian promoters

    Oruba A, Saccani S, van Essen D.

    Nat Commun. 2020 Feb 26;11(1):1075. doi: 10.1038/s41467-020-14950-5.

    PMID: 32103026

  • The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection.


    Sultana T*, van Essen D*, Siol O, Bailly-Bechet M, Philippe C, Zine El Aabidine A, Pioger L, Nigumann P, Saccani S, Andrau JC, Gilbert N, Cristofari G.

    Mol Cell. 2019 May 2;74(3):555-570

    (*equal contribution)

  • A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.


    Piragyte I, Clapes T, Polyzou A, Klein Geltink RI, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeylé L, Langa X, Beckmann CCA, Wlodarski MW, Müller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A, Trompouki E.

    Nat Commun. 2018 Aug 6;9(1):3090. doi: 10.1038/s41467-018-05311-4.

  • Zbtb7a is a transducer for the control of promoter accessibility by NF-kappa B and multiple other transcription factors.


    Ramos Pittol JM, Oruba A, Mittler G, Saccani S*, van Essen D*.

    PLoS Biol. 2018 May 29;16(5):e2004526. doi: 10.1371/journal.pbio.2004526. eCollection 2018 May.

    (* equal contribution)

  • Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci.


    Philippe C, Vargas-Landin DB, Doucet AJ, van Essen D, Vera-Otarola J, Kuciak M, Corbin A, Nigumann P, Cristofari G.

    Elife. 2016 Mar 26;5. pii: e13926. doi: 10.7554/eLife.13926.

  • Regulation of stimulus-inducible gene expression in myeloid cells

    Saccani S, Trabucchi M.

    Semin Immunol. 2015 Feb;27(1):33-43.

    PMID: 25820127
  • Cell-type-specific control of enhancer activity by H3K9 trimethylation.


    Zhu Y, van Essen D*, Saccani S*

    Mol Cell. 2012 May 25;46(4):408-23.

    (* corresponding author)

  • A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation.


    van Essen D, Zhu Y, Saccani S.

    Mol Cell. 2010 Sep 10;39(5):750-60.

  • Two modes of transcriptional activation at native promoters by NF-kappaB p65.


    van Essen D, Engist B, Natoli G, Saccani S.

    PLoS Biol. 2009 Mar 31;7(3):e73. doi: 10.1371/journal.pbio.1000073.

Les équipes de recherche