Carcinogenesis-related chronic active inflammation

Paul HOFMAN, Professor-Clinician, PU-PHCE
  • COVID-19 vaccination and cancer immunotherapy: should they stick together?

    Brest P, Mograbi B, Hofman P, Milano G.

    Br J Cancer. 2022 Jan;126(1):1-3.

    doi: 10.1038/s41416-021-01618-0.

    PMID: 34799696; PMCID: PMC8603902.

  • Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting dysbiosis that contribute to carcinogenesis.

    Yonekura S, Terrisse S, Alves Costa Silva C, Lafarge A, Iebba V, Ferrere G, Goubet AG, Fahrner JE, Lahmar I, Ueda K, Mansouri G, Pizzato E, Ly P, Mazzenga M, Thelemaque C, Fidelle M, Jaulin F, Cartry J, Deloger M, Aglave M, Droin N, Opolon P, Puget A, Mann F, Neunlist M, Bessard A, Aymeric L, Matysiak-Budnik T, Bosq J, Hofman P, Duong CPM, Ugolini S, Quiniou V, Berrard S, Ryffel B, Kepp O, Kroemer G, Routy B, Lordello L, Bani MA, Segata N, Yousef Yengej F, Clevers H, Scoazec JY, Pasolli E, Derosa L, Zitvogel L.

    Cancer Discov. 2021 Dec 20:candisc.0999.2021.

    doi: 10.1158/2159-8290.CD-21-0999. Epub ahead of print.

    PMID: 34930787.

  • Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice.

    Hofman P.

    Cells. 2021 Jan 15;10(1):168.

    doi: 10.3390/cells10010168.

    PMID: 33467720; PMCID: PMC7830674.

  • Automated Analysis of Proliferating Cells Spatial Organisation Predicts Prognosis in Lung Neuroendocrine Neoplasms.

    Bulloni M, Sandrini G, Stacchiotti I, Barberis M, Calabrese F, Carvalho L, Fontanini G, Alì G, Fortarezza F, Hofman P, Hofman V, Kern I, Maiorano E, Maragliano R, Marchiori D, Metovic J, Papotti M, Pezzuto F, Pisa E, Remmelink M, Serio G, Marzullo A, Trabucco SMR, Pennella A, De Palma A, Marulli G, Fassina A, Maffeis V, Nesi G, Naheed S, Rea F, Ottensmeier CH, Sessa F, Uccella S, Pelosi G, Pattini L.

    Cancers (Basel). 2021 Sep 29;13(19):4875.

    doi: 10.3390/cancers13194875.

    PMID: 34638359; PMCID: PMC8508355.

  • The Carcinogen Cadmium Activates Lysine 63 (K63)-Linked Ubiquitin-Dependent Signaling and Inhibits Selective Autophagy.

    Chargui A, Belaid A, Ndiaye PD, Imbert V, Samson M, Guigonis JM, Tauc M, Peyron JF, Poujeol P, Brest P, Hofman P, Mograbi B.

    Cancers (Basel). 2021 May 20;13(10):2490.

    doi: 10.3390/cancers13102490.

    PMID: 34065348; PMCID: PMC8161291.

  • Next-Generation Sequencing with Liquid Biopsies from Treatment-Naïve Non-Small Cell Lung Carcinoma Patients.

    Hofman P.

    Cancers (Basel). 2021 Apr 23;13(9):2049.

    doi: 10.3390/cancers13092049.

    PMID: 33922637; PMCID: PMC8122958.

  • New Targeted Therapies and Immunotherapies for Locally Advanced Periocular Malignant Tumours: Towards a New 'Eye-Sparing' Paradigm?

    Martel A, Lassalle S, Picard-Gauci A, Gastaud L, Montaudie H, Bertolotto C, Nahon-Esteve S, Poissonnet G, Hofman P, Baillif S.

    Cancers (Basel). 2021 Jun 5;13(11):2822.

    doi: 10.3390/cancers13112822.

    PMID: 34198863; PMCID: PMC8201354.

  • Small but Challenging Conjunctival Melanoma: New Insights, Paradigms and Future Perspectives.

    Nahon-Estève S, Bertolotto C, Picard-Gauci A, Gastaud L, Baillif S, Hofman P, Groulier A, Maschi C, Caujolle JP, Lassalle S, Martel A.

    Cancers (Basel). 2021 Nov 14;13(22):5691.

    doi: 10.3390/cancers13225691.

    PMID: 34830847; PMCID: PMC8616295.

  • Targeting histone deacetylase enhances the therapeutic effect of Erastin-induced ferroptosis in EGFR-activating mutant lung adenocarcinoma.

    Zhang T, Sun B, Zhong C, Xu K, Wang Z, Hofman P, Nagano T, Legras A, Breadner D, Ricciuti B, Divisi D, Schmid RA, Peng RW, Yang H, Yao F.

    Transl Lung Cancer Res. 2021 Apr;10(4):1857-1872.

    doi: 10.21037/tlcr-21-303.

    PMID: 34012798; PMCID: PMC8107764.

  • EGFR Status Assessment for Better Care of Early Stage Non-Small Cell Lung Carcinoma: What Is Changing in the Daily Practice of Pathologists?

    Hofman P. 

    Cells. 2021 Aug 21;10(8):2157.

    doi: 10.3390/cells10082157.

    PMID: 34440926; PMCID: PMC8392580.

  • Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients.

    Massa F, Cremoni M, Gérard A, Grabsi H, Rogier L, Blois M, Couzin C, Hassen NB, Rouleau M, Barbosa S, Martinuzzi E, Fayada J, Bernard G, Favre G, Hofman P, Esnault VLM, Czerkinsky C, Seitz-Polski B, Glaichenhaus N, Sicard A. 

    EBioMedicine. 2021 Nov;73:103679.

    doi: 10.1016/j.ebiom.2021.103679. Epub 2021 Nov 8.

    PMID: 34763205; PMCID: PMC8573385.

  • Expert consensus on perioperative immunotherapy for local advanced non-small cell lung cancer.

    Qiu B, Cai K, Chen C, Chen J, Chen KN, Chen QX, Cheng C, Dai TY, Fan J, Fan Z, Hu J, Hu WD, Huang YC, Jiang GN, Jiang J, Jiang T, Jiao WJ, Li HC, Li Q, Liao YD, Liu HX, Liu JF, Liu L, Liu Y, Long H, Luo QQ, Ma HT, Mao NQ, Pan XJ, Tan F, Tan LJ, Tian H, Wang D, Wang WX, Wei L, Wu N, Wu QC, Xiang J, Xu SD, Yang L, Zhang H, Zhang L, Zhang P, Zhang Y, Zhang Z, Zhu K, Zhu Y, Um SW, Oh IJ, Tomita Y, Watanabe S, Nakada T, Seki N, Hida T, Sasada S, Uchino J, Sugimura H, Dermime S, Cappuzzo F, Rizzo S, Cho WC, Crucitti P, Longo F, Lee KY, De Ruysscher D, Vanneste BGL, Furqan M, Sieren JC, Yendamuri S, Merrell KW, Molina JR, Metro G, Califano R, Bongiolatti S, Provencio M, Hofman P, Gao S, He J.

    Transl Lung Cancer Res. 2021 Sep;10(9):3713-3736.

    doi: 10.21037/tlcr-21-634.

    PMID: 34733623; PMCID: PMC8512472.

  • Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma.

    Dufies M, Verbiest A, Cooley LS, Ndiaye PD, He X, Nottet N, Souleyreau W, Hagege A, Torrino S, Parola J, Giuliano S, Borchiellini D, Schiappa R, Mograbi B, Zucman-Rossi J, Bensalah K, Ravaud A, Auberger P, Bikfalvi A, Chamorey E, Rioux-Leclercq N, Mazure NM, Beuselinck B, Cao Y, Bernhard JC, Ambrosetti D, Pagès G.

    Commun Biol. 2021 Feb 5;4(1):166.

    doi: 10.1038/s42003-021-01653-w.

    PMID: 33547392; PMCID: PMC7865059.

  • Detection of EGFR Mutations From Plasma of NSCLC Patients Using an Automatic Cartridge-Based PCR System.

    Heeke S, Hofman V, Benzaquen J, Otto J, Tanga V, Zahaf K, Allegra M, Long-Mira E, Lassalle S, Marquette CH, Ilie M, Hofman P.

    Front Pharmacol. 2021 Apr 14;12:657743.

    doi: 10.3389/fphar.2021.657743.

    PMID: 33935776; PMCID: PMC8079969.

  • Liquid biopsy for lung cancer screening: Usefulness of circulating tumor cells and other circulating blood biomarkers.

    Hofman P.

    Cancer Cytopathol. 2021 May;129(5):341-346.

    doi: 10.1002/cncy.22367. Epub 2020 Oct 2.

    PMID: 33007153.

  • To inhibit or to boost the ATP/P2RX7 pathway to fight cancer-that is the question.

    Janho Dit Hreich S, Benzaquen J, Hofman P, Vouret-Craviari V.

    Purinergic Signal. 2021 Dec;17(4):619-631.

    doi: 10.1007/s11302-021-09811-9. Epub 2021 Aug 4.

    PMID: 34347213; PMCID: PMC8677881.

  • More light on cancer and COVID-19 reciprocal interaction.

    Brest P, Mograbi B, Hofman P, Milano G.

    Br J Cancer. 2021 Apr;124(8):1344-1345.

    doi: 10.1038/s41416-020-01246-0. Epub 2021 Feb 3.

    PMID: 33531686; PMCID: PMC8039039.

  • Perspectives and Issues in the Assessment of SMARCA4 Deficiency in the Management of Lung Cancer Patients.

    Armon S, Hofman P, Ilié M.

    Cells. 2021 Jul 29;10(8):1920.

    doi: 10.3390/cells10081920.

    PMID: 34440689; PMCID: PMC8394288.

  • Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies.

    Jaune E, Cavazza E, Ronco C, Grytsai O, Abbe P, Tekaya N, Zerhouni M, Beranger G, Kaminski L, Bost F, Gesson M, Tulic M, Hofman P, Ballotti R, Passeron T, Botton T, Benhida R, Rocchi S.

    Cell Death Dis. 2021 Jan 11;12(1):64.

    doi: 10.1038/s41419-020-03344-6.

    PMID: 33431809; PMCID: PMC7801734.

  • From biomarkers to therapeutic targets: the promise of PD-L1 in thyroid autoimmunity and cancer.

    D'Andréa G, Lassalle S, Guevara N, Mograbi B, Hofman P.

    Theranostics. 2021 Jan 1;11(3):1310-1325.

    doi: 10.7150/thno.50333.

    PMID: 33391536; PMCID: PMC7738901.

  • Impact of expert pathologic review of thymic epithelial tumours on diagnosis and management in a real-life setting: A RYTHMIC study.

    Molina TJ, Bluthgen MV, Chalabreysse L, de Montpréville VT, de Muret A, Dubois R, Hofman V, Lantuejoul S, le Naoures C, Mansuet-Lupo A, Parrens M, Piton N, Rouquette I, Secq V, Girard N, Marx A, Besse B.

    Eur J Cancer. 2021 Jan;143:158-167.

    doi: 10.1016/j.ejca.2020.11.011. Epub 2020 Dec 11.

    PMID: 33316754.

  • The Unforeseen Path to the Superior Vena Cava.

    Boutros J, Benzaquen J, Marquette CH, Leroy S.

    Am J Respir Crit Care Med. 2021 Aug 1;204(3):e51-e53.

    doi: 10.1164/rccm.202011-4106IM.

    PMID: 34166167.


  • A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy.

    Douguet L, Janho Dit Hreich S, Benzaquen J, Seguin L, Juhel T, Dezitter X, Duranton C, Ryffel B, Kanellopoulos J, Delarasse C, Renault N, Furman C, Homerin G, Féral C, Cherfils-Vicini J, Millet R, Adriouch S, Ghinet A, Hofman P, Vouret-Craviari V.

    Nat Commun. 2021 Jan 28;12(1):653.

    doi: 10.1038/s41467-021-20912-2.

    PMID: 33510147; PMCID: PMC7843983.

  • PD-L1 regulation revisited: impact on immunotherapeutic strategies.

    Lucibello G, Mograbi B, Milano G, Hofman P, Brest P.

    Trends Mol Med. 2021 Sep;27(9):868-881.

    doi: 10.1016/j.molmed.2021.06.005. Epub 2021 Jun 26.

    PMID: 34187739.

  • Prospective Multicenter Validation of the Detection of ALK Rearrangements of Circulating Tumor Cells for Noninvasive Longitudinal Management of Patients With Advanced NSCLC.

    Ilié M, Mazières J, Chamorey E, Heeke S, Benzaquen J, Thamphya B, Boutros J, Tiotiu A, Fayada J, Cadranel J, Poudenx M, Moro-Sibilot D, Barlesi F, Thariat J, Clément-Duchêne C, Tomasini P, Hofman V, Marquette CH, Hofman P; STALKLUNG01 Study Consortium Investigators.

    J Thorac Oncol. 2021 May;16(5):807-816.

    doi: 10.1016/j.jtho.2021.01.1617. Epub 2021 Feb 3.

    PMID: 33545389.

  • New technologies for improved relevance in miRNA research.

    Jacquet K, Vidal-Cruchez O, Rezzonico R, Nicolini VJ, Mograbi B, Hofman P, Vassaux G, Mari B, Brest P.

    Trends Genet. 2021 Dec;37(12):1060-1063.

    doi: 10.1016/j.tig.2021.08.006. Epub 2021 Aug 30.

    PMID: 34474931.

  • Using Genetics To Dissect SARS-CoV-2 Infection.

    Brest P, Mograbi B, Hofman P, Milano G.

    Trends Genet. 2021 Mar;37(3):203-204.

    doi: 10.1016/j.tig.2020.11.007. Epub 2020 Nov 26.

    PMID: 33309104; PMCID: PMC7689311.

  • Association of TRF2 expression and myeloid-derived suppressor cells infiltration with clinical outcome of patients with cutaneous melanoma.

    Ilié M, Lantéri E, Chamorey E, Thamphya B, Hamila M, Montaudié H, Picard-Gauci A, Gardrat S, Passeron T, Lassalle S, Long-Mira E, Cherfils-Vicini J, Gilson E, Hofman V, Hofman P.

    Oncoimmunology. 2021 Mar 19;10(1):1901446.

    doi: 10.1080/2162402X.2021.1901446.

    PMID: 33796413; PMCID: PMC7993190.


  • TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms.

    Peyre L, Meyer M, Hofman P, Roux J. 

    Br J Cancer. 2021 Jan;124(1):91-101.

    doi: 10.1038/s41416-020-01177-w. Epub 2020 Dec 1.

    PMID: 33257838; PMCID: PMC7782794.

  • Genomic and evolutionary classification of lung cancer in never smokers.

    Zhang T, Joubert P, Ansari-Pour N, Zhao W, Hoang PH, Lokanga R, Moye AL, Rosenbaum J, Gonzalez-Perez A, Martínez-Jiménez F, Castro A, Muscarella LA, Hofman P, Consonni D, Pesatori AC, Kebede M, Li M, Gould Rothberg BE, Peneva I, Schabath MB, Poeta ML, Costantini M, Hirsch D, Heselmeyer-Haddad K, Hutchinson A, Olanich M, Lawrence SM, Lenz P, Duggan M, Bhawsar PMS, Sang J, Kim J, Mendoza L, Saini N, Klimczak LJ, Islam SMA, Otlu B, Khandekar A, Cole N, Stewart DR, Choi J, Brown KM, Caporaso NE, Wilson SH, Pommier Y, Lan Q, Rothman N, Almeida JS, Carter H, Ried T, Kim CF, Lopez-Bigas N, Garcia-Closas M, Shi J, Bossé Y, Zhu B, Gordenin DA, Alexandrov LB, Chanock SJ, Wedge DC, Landi MT.

    Nat Genet. 2021 Sep;53(9):1348-1359.

    doi: 10.1038/s41588-021-00920-0. Epub 2021 Sep 6.

    PMID: 34493867; PMCID: PMC8432745.

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Klionsky DJ, ..., Brest P, ..., Hofman P, ..., Mograbi B, et al .

    Autophagy. 2021 Jan;17(1):1-382.

    doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8.

    PMID: 33634751; PMCID: PMC7996087.

  • Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.

    Pandiani C, Strub T, Nottet N, Cheli Y, Gambi G, Bille K, Husser C, Dalmasso M, Béranger G, Lassalle S, Magnone V, Pédeutour F, Irondelle M, Maschi C, Nahon-Estève S, Martel A, Caujolle JP, Hofman P, LeBrigand K, Davidson I, Baillif S, Barbry P, Ballotti R, Bertolotto C.

    Cell Death Differ. 2021 Jun;28(6):1990-2000.

    doi: 10.1038/s41418-020-00730-7. Epub 2021 Jan 18.

    PMID: 33462406; PMCID: PMC8185008.

  • Mutational Profile Evaluates Response and Survival to First-Line Chemotherapy in Lung Cancer.

    He Y, Song L, Wang H, Chen P, Liu Y, Sun H, Li X, Dang S, Liu G, Liu X, Chen S, Zhang X, Hofman P, Uchino J, Park HS, Pacheco JM, Tabbò F, Xu M, Dai J, He K, Yang Y, Zhou C; written on behalf of the AME Lung Cancer Collaborative Group.

    Adv Sci (Weinh). 2020 Dec 30;8(4):2003263.

    doi: 10.1002/advs.202003263.

    PMID: 33643802; PMCID: PMC7887584.

  • Targeting netrin-3 in small cell lung cancer and neuroblastoma.

    Jiang S, Richaud M, Vieugué P, Rama N, Delcros JG, Siouda M, Sanada M, Redavid AR, Ducarouge B, Hervieu M, Breusa S, Manceau A, Gattolliat CH, Gadot N, Combaret V, Neves D, Ortiz-Cuaran S, Saintigny P, Meurette O, Walter T, Janoueix-Lerosey I, Hofman P, Mulligan P, Goldshneider D, Mehlen P, Gibert B.

    EMBO Mol Med. 2021 Apr 9;13(4):e12878.

    doi: 10.15252/emmm.202012878. Epub 2021 Mar 15.

    PMID: 33719214; PMCID: PMC8033513.

  • Global impact of the COVID-19 pandemic on cytopathology practice: Results from an international survey of laboratories in 23 countries.

    Vigliar E, Cepurnaite R, Alcaraz-Mateos E, Ali SZ, Baloch ZW, Bellevicine C, Bongiovanni M, Botsun P, Bruzzese D, Bubendorf L, Büttner R, Canberk S, Capitanio A, Casadio C, Cazacu E, Cochand-Priollet B, D'Amuri A, Eloy C, Engels M, Fadda G, Fontanini G, Fulciniti F, Hofman P, Iaccarino A, Ieni A, Jiang XS, Kakudo K, Kern I, Kholova I, Liu C, Lobo A, Lozano MD, Malapelle U, Maleki Z, Michelow P, Musayev J, Özgün G, Oznur M, Peiró Marqués FM, Pisapia P, Poller D, Pyzlak M, Robinson B, Rossi ED, Roy-Chowdhuri S, Saieg M, Savic Prince S, Schmitt FC, Javier Seguí Iváñez F, Štoos-Veić T, Sulaieva O, Sweeney BJ, Tuccari G, van Velthuysen ML, VanderLaan PA, Vielh P, Viola P, Voorham R, Weynand B, Zeppa P, Faquin WC, Pitman MB, Troncone G.

    Cancer Cytopathol. 2020 Dec;128(12):885-894.

    doi: 10.1002/cncy.22373. Epub 2020 Oct 27.

    PMID: 33108683.

  • Predictive molecular pathology in non-small cell lung cancer in France: The past, the present and the perspectives.

    Hofman P, Rouleau E, Sabourin JC, Denis M, Deleuze JF, Barlesi F, Laurent-Puig P.

    Cancer Cytopathol. 2020 Sep;128(9):601-610.

    doi: 10.1002/cncy.22318.

    PMID: 32885912.

  • Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics.

    Meyer M, Paquet A, Arguel MJ, Peyre L, Gomes-Pereira LC, Lebrigand K, Mograbi B, Brest P, Waldmann R, Barbry P, Hofman P, Roux J.

    Cell Syst. 2020 Oct 21;11(4):367-374.e5.

    doi: 10.1016/j.cels.2020.08.019. Epub 2020 Sep 23.

    PMID: 33099406.

  • Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study.

    Marquette CH, Boutros J, Benzaquen J, Ferreira M, Pastre J, Pison C, Padovani B, Bettayeb F, Fallet V, Guibert N, Basille D, Ilie M, Hofman V, Hofman P; AIR project Study Group.

    Lancet Respir Med. 2020 Jul;8(7):709-716.

    doi: 10.1016/S2213-2600(20)30081-3. Erratum in: Lancet Respir Med. 2020 Dec;8(12):e94.

    PMID: 32649919.

  • PD-L1 Expression in 65 Conjunctival Melanomas and Its Association with Clinical Outcome.

    Lassalle S, Nahon-Esteve S, Frouin E, Boulagnon-Rombi C, Josselin N, Cassoux N, Barnhill R, Scheller B, Baillif S, Hofman P.

    Int J Mol Sci. 2020 Nov 30;21(23):9147.

    doi: 10.3390/ijms21239147.

    PMID: 33266349; PMCID: PMC7731195.

  • A multifactorial score including autophagy for prognosis and care of COVID-19 patients

    Domdom MA, Brest P, Grosjean I, Roméo B, Landi MT, Gal J, Klionsky DJ, Hofman P, Mograbi B.

    Autophagy. 2020 Dec;16(12):2276-2281.

    doi: 10.1080/15548627.2020.1844433.

    PMID: 33249989; PMCID: PMC7751655.

  • Comparison of three sequencing panels used for the assessment of tumor mutational burden in non-small cell lung cancer demonstrates low comparability

    Heeke S, Benzaquen J, Hofman V, Long-Mira E, Lespinet V, Bordone O, Marquette CH, Delingette H, Ilié M, Hofman P.
    J Thorac Oncol. 2020 May 22. pii: S1556-0864(20)30417-2. doi: 10.1016/j.jtho.2020.05.013.
    PMID: 32450274

  • Real-world assessment of the BRAF status in non-squamous cell lung carcinoma using VE1 immunohistochemistry: A single laboratory experience (LPCE, Nice, France)

    Hofman V, Benzaquen J, Heeke S, Lassalle S, Poudenx M, Long E, Lantéri E, Bordone O, Lespinet V, Tanga V, Bonnetaud C, Bille Y, Ilié M, Marquette C, Barlesi F, Boutros J, Hofman P.

    Lung Cancer. 2020 May 5;145:58-62.

    PubMed PMID: 32408133

  • Possible consequences of the COVID-19 pandemic on the use of biospecimens from cancer biobanks for research in academia and bioindustry

     Paul Hofman, Pascal Puchois, Patrick Brest, Hicham Lahlou, Daniel Simeon-Dubach

    Nat Med. 2020 May 7.


    PMID: 32382152

  • Prospective evaluation of NGS-based liquid biopsy in untreated late stage non-squamous lung carcinoma in a single institution.

    Heeke S, Hofman V, Ilié M, Allegra M, Lespinet V, Bordone O, Benzaquen J, Boutros J, Poudenx M, Lalvée S, Tanga V, Salacroup C, Bonnetaud C, Marquette CH, Hofman P.

    J Transl Med. 2020 Feb 17;18(1):87. doi: 10.1186/s12967-020-02259-2.

    PMID: 32066459

  • Targeted Assessment of the EGFR Status as Reflex Testing in Treatment-Naive Non-Squamous Cell Lung Carcinoma Patients: A Single Laboratory Experience (LPCE, Nice, France)

    Lassalle S, Hofman V, Heeke S, Benzaquen J, Long E, Poudenx M, Lantéri E, Boutros J, Tanga V, Zahaf K, Lalvée S, Lespinet V, Bordone O, Félix JM, Bonnetaud C, Marquette C, Ilie M, Hofman P.

    Cancers (Basel). 2020 Apr 13;12(4). pii: E955.

    doi: 10.3390/cancers12040955.

    PubMed PMID: 32294880.

  • Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease

    Homerin G, Jawhara S, Dezitter X, Baudelet D, Dufrénoy P, Rigo B, Millet R, Furman C, Ragé G, Lipka E, Farce A, Renault N, Sendid B, Charlet R, Leroy J, Phanithavong M, Richeval C, Wiart JF, Allorge D, Adriouch S, Vouret-Craviari V, Ghinet A.

    J Med Chem. 2020 Mar 12;63(5):2074-2094. doi: 10.1021/acs.jmedchem.9b00584. Epub 2019 Sep 27.

    PubMed PMID: 31525963

  • Open Questions for Harnessing Autophagy-Modulating Drugs in the SARS-CoV-2 War. 


    Brest P, Benzaquen J, Klionsky DJ, Hofman P, Mograbi B.

    Autophagy. 2020 Dec;16(12):2267-2270.

    doi: 10.1080/15548627.2020.1779531.

    PMID: 32521191; PMCID: PMC7751564.

  • Hyperprogression under Immune Checkpoint Inhibitor: a potential role for germinal immunogenetics.

    Refae S, Gal J, Brest P, Giacchero D, Borchiellini D, Ebran N, Peyrade F, Guigay J, Milano G, Saada-Bouzid E.

    Sci Rep. 2020 Feb 27;10(1):3565. doi: 10.1038/s41598-020-60437-0.

    PMID: 32107407

  • Germinal Immunogenetics predict treatment outcome for PD-1/PD-L1 checkpoint inhibitors.

    Refae S, Gal J, Ebran N, Otto J, Borchiellini D, Peyrade F, Chamorey E, Brest P, Milano G, Saada-Bouzid E.

    Invest New Drugs. 2020 Feb;38(1):160-171. doi: 10.1007/s10637-019-00845-w. Epub 2019 Aug 11.

    PMID: 31402427

  • Genetic alterations of malignant pleural mesothelioma: association with tumor heterogeneity and overall survival.

    Quetel L, Meiller C, Assié JB, Blum Y, Imbeaud S, Montagne F, Tranchant R, de Wolf J, Caruso S, Copin MC, Hofman V, Gibault L, Badoual C, Pintilie E, Hofman P, Monnet I, Scherpereel A, Le Pimpec-Barthes F, Zucman-Rossi J, Jaurand MC, Jean D.

    Mol Oncol. 2020 Feb 21. doi: 10.1002/1878-0261.12651. 

    PMID: 32083805

  • Enhancing Cooperation Between Academic Biobanks and Biomedical Industry: Better Mutual Understanding and New Collaborative Models Are Needed.

    Simeon-Dubach D, Roehrl MH, Hofman P, Puchois P.

    Biopreserv Biobank. 2020 Feb 11. doi: 10.1089/bio.2019.0095. [Epub ahead of print] No abstract available.

    PMID: 32043910

  • Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF): Results of the

    Beau-Faller M, Pencreach E, Leduc C, Blons H, Merlio JP, Bringuier PP, de Fraipont F, Escande F, Lemoine A, Ouafik L, Denis M, Hofman P, Lacave R, Melaabi S, Langlais A, Missy P, Morin F, Moro-Sibilot D, Barlesi F, Cadranel J; French Cooperative Thoracic Intergroup (IFCT).

    Lung Cancer. 2020 Feb;140:19-26. doi: 10.1016/j.lungcan.2019.10.013. Epub 2019 Nov 15.

    PMID: 31841714

  • Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF)

    Beau-Faller M, Pencreach E, Leduc C, Blons H, Merlio JP, Bringuier PP, de Fraipont F, Escande F, Lemoine A, Ouafik L, Denis M, Hofman P, Lacave R, Melaabi S, Langlais A, Missy P, Morin F, Moro-Sibilot D, Barlesi F, Cadranel J; French Cooperative Thoracic Intergroup (IFCT).

     Independent prognostic value of ultra-sensitive quantification of tumor pre-treatment T790M subclones in EGFR mutated non-small cell lung cancer (NSCLC) treated by first/second generation TKI, depends on variant allele frequency (VAF): Results of the French cooperative thoracic intergroup (IFCT) biomarkers France project.

    Lung Cancer. 2020 Feb;140:19-26.

    doi: 10.1016/j.lungcan.2019.10.013. Epub 2019 Nov 15.

    PMID: 31841714.

  • CT-guided percutaneous biopsies of mediastinal and paramediastinal masses in the lateral decubitus position.

    Padovani B, Boutros J, Marquette CH, Hofman V, Ducreux D, Mouroux J, Diascorn Y, Leroy S.

    Eur Radiol. 2020 Jun;30(6):3146-3151.

    doi: 10.1007/s00330-020-06659-2. Epub 2020 Feb 17.

    PMID: 32065281.

  • The power of immunotherapy plus platinum-based chemotherapy for locally advanced or early stage non-small cell lung cancer.

    Hofman P.

    Ann Transl Med. 2020 Mar;8(5):151.

    doi: 10.21037/atm.2020.01.91.

    PubMed PMID: 32309300; PubMed Central PMCID: PMC7154477.

  • VEGF-Related Germinal Polymorphisms May Identify a Subgroup of Breast Cancer Patients with Favorable Outcome under Bevacizumab-Based Therapy

    Gal J, Milano G, Brest P, Ebran N, Gilhodes J, Llorca L, Dubot C, Romieu G, Desmoulins I, Brain E, Goncalves A, Ferrero JM, Cottu PH, Debled M, Tredan O, Chamorey E, Merlano MC, Lemonnier J, Etienne-Grimaldi MC, Pierga JY.

    VEGF-Related Germinal Polymorphisms May Identify a Subgroup of Breast Cancer Patients with Favorable Outcome under Bevacizumab-Based Therapy-A Message from COMET, a French Unicancer Multicentric Study.

    Pharmaceuticals (Basel). 2020 Nov 23;13(11):414.

    doi: 10.3390/ph13110414.

    PMID: 33238394; PMCID: PMC7700430.

  • "Interchangeability" of PD-L1 immunohistochemistry assays: a meta-analysis of diagnostic accuracy.

    Torlakovic E, Lim HJ, Adam J, Barnes P, Bigras G, Chan AWH, Cheung CC, Chung JH, Couture C, Fiset PO, Fujimoto D, Han G, Hirsch FR, Ilie M, Ionescu D, Li C, Munari E, Okuda K, Ratcliffe MJ, Rimm DL, Ross C, Røge R, Scheel AH, Soo RA, Swanson PE, Tretiakova M, To KF, Vainer GW, Wang H, Xu Z, Zielinski D, Tsao MS.

    Mod Pathol. 2020 Jan;33(1):4-17.

    doi: 10.1038/s41379-019-0327-4. Epub 2019 Aug 5.

    PMID: 31383961; PMCID: PMC6927905.

  • Host Polymorphisms May Impact SARS-CoV-2 Infectivity.

    Brest P, Refae S, Mograbi B, Hofman P, Milano G.

    Trends Genet. 2020 Nov;36(11):813-815.

    doi: 10.1016/j.tig.2020.08.003. Epub 2020 Aug 10.

    PMID: 32828550; PMCID: PMC7416730.

  • P2RX7B is a new theranostic marker for lung adenocarcinoma patients.

    Benzaquen J, Dit Hreich SJ, Heeke S, Juhel T, Lalvee S, Bauwens S, Saccani S, Lenormand P, Hofman V, Butori M, Leroy S, Berthet JP, Marquette CH, Hofman P, Vouret-Craviari V.

    Theranostics. 2020 Aug 29;10(24):10849-10860. doi: 10.7150/thno.48229.

    PMID: 33042257; PMCID: PMC7532666.

  • Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives.

    Martel A, Baillif S, Nahon-Esteve S, Gastaud L, Bertolotto C, Roméo B, Mograbi B, Lassalle S, Hofman P.

    Cancers (Basel). 2020 Nov 6;12(11):3284. doi: 10.3390/cancers12113284.

    PMID: 33172021; PMCID: PMC7694640.

  • Challenges and issues surrounding the use for translational research of human samples obtained during the COVID-19 pandemic from lung cancer patients.

    Hofman P.

    Transl Lung Cancer Res. 2020 Aug;9(4):1543-1553.

    doi: 10.21037/tlcr-20-594.

    PMID: 32953526; PMCID: PMC7481610.

  • New insights into the interaction of the immune system with non-small cell lung carcinomas.

    Hofman P.

    Transl Lung Cancer Res. 2020 Oct;9(5):2199-2213.

    doi: 10.21037/tlcr-20-178.

    PMID: 33209644; PMCID: PMC7653157.

  • A Single-Cell Atlas of the Human Healthy Airways.

    Deprez M, Zaragosi LE, Truchi M, Becavin C, Ruiz García S, Arguel MJ, Plaisant M, Magnone V, Lebrigand K, Abelanet S, Brau F, Paquet A, Pe'er D, Marquette CH, Leroy S, Barbry P.

    Am J Respir Crit Care Med. 2020 Dec 15;202(12):1636-1645.

    doi: 10.1164/rccm.201911-2199OC.

    PMID: 32726565.

  • Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach

    Galateau Salle F, Le Stang N, Tirode F, Courtiol P, Nicholson AG, Tsao MS, Tazelaar HD, Churg A, Dacic S, Roggli V, Pissaloux D, Maussion C, Moarii M, Beasley MB, Begueret H, Chapel DB, Copin MC, Gibbs AR, Klebe S, Lantuejoul S, Nabeshima K, Vignaud JM, Attanoos R, Brcic L, Capron F, Chirieac LR, Damiola F, Sequeiros R, Cazes A, Damotte D, Foulet A, Giusiano-Courcambeck S, Hiroshima K, Hofman V, Husain AN, Kerr K, Marchevsky A, Paindavoine S, Picquenot JM, Rouquette I, Sagan C, Sauter J, Thivolet F, Brevet M, Rouvier P, Travis WD, Planchard G, Weynand B, Clozel T, Wainrib G, Fernandez-Cuesta L, Pairon JC, Rusch V, Girard N.

    Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center.

    J Thorac Oncol. 2020 Jun;15(6):1037-1053.

    doi: 10.1016/j.jtho.2020.01.025. Epub 2020 Mar 9.

    PMID: 32165206.

  • Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.

    Fabbri L, Dufies M, Lacas-Gervais S, Gardie B, Gad-Lapiteau S, Parola J, Nottet N, Meyenberg Cunha de Padua M, Contenti J, Borchiellini D, Ferrero JM, Leclercq NR, Ambrosetti D, Mograbi B, Richard S, Viotti J, Chamorey E, Sadaghianloo N, Rouleau M, Craigen WJ, Mari B, Clavel S, Pagès G, Pouysségur J, Bost F, Mazure NM.

    Theranostics. 2020 Feb 3;10(6):2696-2713.

    doi: 10.7150/thno.41001.

    PMID: 32194829; PMCID: PMC7052902.

  • Allergy Evaluation of Hypersensitivity to Platinum Salts and Taxanes: A Six-Year Experience.

    Pradelli J, Verdoire P, Boutros J, Frin AC, Follana P, Duquesne J, Marquette CH, Benzaquen J, Ben Hayoun M, Leroy S.

    J Allergy Clin Immunol Pract. 2020 May;8(5):1658-1664.

    doi: 10.1016/j.jaip.2019.12.032. Epub 2020 Jan 7.

    PMID: 31918017.

  • Long Term Pharmacological Perturbation of Autophagy in Mice: Are HCQ Injections a Relevant Choice?

    Masson JD, Blanchet B, Periou B, Authier FJ, Mograbi B, Gherardi RK, Crépeaux G.

    Biomedicines. 2020 Mar 1;8(3):47.

    doi: 10.3390/biomedicines8030047.

    PMID: 32121613; PMCID: PMC7148514.

  • Pyroglutamide-Based P2X7 Receptor Antagonists Targeting Inflammatory Bowel Disease.

    Homerin G, Jawhara S, Dezitter X, Baudelet D, Dufrénoy P, Rigo B, Millet R, Furman C, Ragé G, Lipka E, Farce A, Renault N, Sendid B, Charlet R, Leroy J, Phanithavong M, Richeval C, Wiart JF, Allorge D, Adriouch S, Vouret-Craviari V, Ghinet A.

    J Med Chem. 2020 Mar 12;63(5):2074-2094.

    doi: 10.1021/acs.jmedchem.9b00584. Epub 2019 Sep 27.

    PMID: 31525963.

  • QT Interval Prolongation Under Hydroxychloroquine/Azithromycin Association for Inpatients With SARS-CoV-2 Lower Respiratory Tract Infection.

    Bun SS, Taghji P, Courjon J, Squara F, Scarlatti D, Theodore G, Baudouy D, Sartre B, Labbaoui M, Dellamonica J, Doyen D, Marquette CH, Levraut J, Esnault V, Bun SS, Ferrari E.

    Clin Pharmacol Ther. 2020 Nov;108(5):1090-1097.

    doi: 10.1002/cpt.1968. Epub 2020 Jul 20.

    PMID: 32588427; PMCID: PMC7361407.

  • Circulating Tumour DNA Is an Independent Prognostic Biomarker for Survival in Metastatic BRAF or NRAS-Mutated Melanoma Patients.

    Herbreteau G, Vallée A, Knol AC, Théoleyre S, Quéreux G, Frénard C, Varey E, Hofman P, Khammari A, Dréno B, Denis MG.

    Cancers (Basel). 2020 Jul 11;12(7):1871.

    doi: 10.3390/cancers12071871.

    PMID: 32664549; PMCID: PMC7409003.

  • Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC.

    Meyenberg Cunha-de Padua M, Fabbri L, Dufies M, Lacas-Gervais S, Contenti J, Voyton C, Fazio S, Irondelle M, Mograbi B, Rouleau M, Sadaghianloo N, Rovini A, Brenner C, Craigen WJ, Bourgeais J, Herault O, Bost F, Mazure NM.

    Cancers (Basel). 2020 Nov 23;12(11):3484.

    doi: 10.3390/cancers12113484.

    PMID: 33238609; PMCID: PMC7700438.

  • DNA FISH Diagnostic Assay on Cytological Samples of Thyroid Follicular Neoplasms.

    Vielh P, Balogh Z, Suciu V, Richon C, Job B, Meurice G, Valent A, Lacroix L, Marty V, Motte N, Dessen P, Caillou B, Ghuzlan AA, Bidart JM, Lazar V, Hofman P, Scoazec JY, El-Naggar AK, Schlumberger M.

    Cancers (Basel). 2020 Sep 6;12(9):2529.

    doi: 10.3390/cancers12092529.

    PMID: 32899953; PMCID: PMC7564487.

  • Lung cancer biomarker testing: perspective from Europe.

    Thunnissen E, Weynand B, Udovicic-Gagula D, Brcic L, Szolkowska M, Hofman P, Smojver-Ježek S, Anttila S, Calabrese F, Kern I, Skov B, Perner S, Dale VG, Eri Z, Haragan A, Leonte D, Carvallo L, Prince SS, Nicholson S, Sansano I, Ryska A.

    Transl Lung Cancer Res. 2020 Jun;9(3):887-897.

    doi: 10.21037/tlcr.2020.04.07.

    PMID: 32676354; PMCID: PMC7354119.

  • Immunotherapy beyond progression in patients with advanced non-small cell lung cancer.

    Ge X, Zhang Z, Zhang S, Yuan F, Zhang F, Yan X, Han X, Ma J, Wang L, Tao H, Li X, Zhi X, Huang Z, Hofman P, Prelaj A, Banna GL, Mutti L, Hu Y, Wang J.

    Transl Lung Cancer Res. 2020 Dec;9(6):2391-2400.

    doi: 10.21037/tlcr-20-1252.

    PMID: 33489801; PMCID: PMC7815351.

  • Comparison of unsupervised machine-learning methods to identify metabolomic signatures in patients with localized breast cancer.

    Gal J, Bailleux C, Chardin D, Pourcher T, Gilhodes J, Jing L, Guigonis JM, Ferrero JM, Milano G, Mograbi B, Brest P, Chateau Y, Humbert O, Chamorey E.

    Comput Struct Biotechnol J. 2020 Jun 3;18:1509-1524.

    doi: 10.1016/j.csbj.2020.05.021.

    PMID: 32637048; PMCID: PMC7327012.

  • The Molecular Pathology of Eye Tumors: A 2019 Update Main Interests for Routine Clinical Practice.

    Nahon-Esteve S, Martel A, Maschi C, Caujolle JP, Baillif S, Lassalle S, Hofman P.

    Curr Mol Med. 2019;19(9):632-664. doi: 10.2174/1566524019666190726161044.

    PMID: 31418658

  • Multiplexed Immunohistochemistry for Molecular and Immune Profiling in Lung Cancer-Just About Ready for Prime-Time?

    Hofman P, Badoual C, Henderson F, Berland L, Hamila M, Long-Mira E, Lassalle S, Roussel H, Hofman V, Tartour E, Ilié M.

    Cancers (Basel). 2019 Feb 27;11(3). pii: E283. doi: 10.3390/cancers11030283. Review.

    PMID: 30818873

  • Circulating Tumor Cell Detection in Lung Cancer: But to What End?

    Hofman V, Heeke S, Marquette CH, Ilié M, Hofman P.

    Cancers (Basel). 2019 Feb 23;11(2). pii: E262. doi: 10.3390/cancers11020262. Review.

    PMID: 30813420

  • The challenges of evaluating predictive biomarkers using small biopsy tissue samples and liquid biopsies from non-small cell lung cancer patients.

    Hofman P. 

    J Thorac Dis. 2019 Jan;11(Suppl 1):S57-S64. doi: 10.21037/jtd.2018.11.85. Review.

    PMID: 30775028

  • Advances in theranostic biomarkers for lung cancer from clinical to molecular pathology.

    Hofman P.

    J Thorac Dis. 2019 Jan;11(Suppl 1):S1-S2. doi: 10.21037/jtd.2018.10.28. No abstract available.

    PMID: 30775022

  • The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again.

    Hofman P, Ayache N, Barbry P, Barlaud M, Bel A, Blancou P, Checler F, Chevillard S, Cristofari G, Demory M, Esnault V, Falandry C, Gilson E, Guérin O, Glaichenhaus N, Guigay J, Ilié M, Mari B, Marquette CH, Paquis-Flucklinger V, Prate F, Saintigny P, Seitz-Polsky B, Skhiri T, Van Obberghen-Schilling E, Van Obberghen E, Yvan-Charvet L.

    Cancers (Basel). 2019 Feb 21;11(2). pii: E250. doi: 10.3390/cancers11020250.

    PMID: 30795607

  • Lung Cancer Screening, Towards a Multidimensional Approach: Why and How?

    Benzaquen J, Boutros J, Marquette C, Delingette H, Hofman P.

    Cancers (Basel). 2019 Feb 12;11(2). pii: E212. doi: 10.3390/cancers11020212. Review.

    PMID: 30759893

  • The Desire to Better Understand Older Adults with Solid Tumors to Improve Management: Assessment and Guided Interventions-The French PACA EST Cohort Experience.

    Boulahssass R, Gonfrier S, Champigny N, Lassalle S, François E, Hofman P, Guerin O.

    Cancers (Basel). 2019 Feb 7;11(2). pii: E192.

    PMID: 30736406

  • Circulating free tumor DNA in non-small cell lung cancer (NSCLC): clinical application and future perspectives.

    Herbreteau G, Vallée A, Charpentier S, Normanno N, Hofman P, Denis MG.

    J Thorac Dis. 2019 Jan;11(Suppl 1):S113-S126. doi: 10.21037/jtd.2018.12.18. Review.

    PMID: 30775034

  • Programmed death ligand 1 immunohistochemistry in non-small cell lung carcinoma.

    Lantuejoul S, Damotte D, Hofman V, Adam J.

    J Thorac Dis. 2019 Jan;11(Suppl 1):S89-S101. doi: 10.21037/jtd.2018.12.103. Review.

    PMID: 30775032

  • Resistances to EGFR tyrosine kinase inhibitors in lung cancer-how to routinely track them in a molecular pathology laboratory?

    Hofman V, Hofman P.

    J Thorac Dis. 2019 Jan;11(Suppl 1):S65-S70. doi: 10.21037/jtd.2018.11.76. Review.

    PMID:  30775029



  • Thoracic oncology and tumor mutational burden: Towards new challenges for the pathologist?

    Hofman P.

    Ann Pathol (French). 2019 Jan 30. pii: S0242-6498(18)30193-7.

    PMID: 30711336


  • Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.

    Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C.

    Cell Metab. 2019 Jan 8;29(1):124-140.e10.

    PMID: 30293773

  • Is the onset of adverse effects of immunotherapy always bad news for the patients…?-certainly not!

    Hofman P.

    Ann Transl Med. 2019 Mar;7(Suppl 1):S5. doi: 10.21037/atm.2019.01.14. No abstract available.

    PMID: 31032286

  • Lysosomal acid ceramidase ASAH1 controls the transition between invasive and proliferative phenotype in melanoma cells.

    Leclerc J, Garandeau D, Pandiani C, Gaudel C, Bille K, Nottet N, Garcia V, Colosetti P, Pagnotta S, Bahadoran P, Tondeur G, Mograbi B, Dalle S, Caramel J, Levade T, Ballotti R, Andrieu-Abadie N, Bertolotto C.

    Oncogene. 2019 Feb;38(8):1282-1295.

    doi:10.1038/s41388-018-0500-0. Epub 2018 Sep 25.

    PMID: 30254208.

  • VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness.

    Ndiaye PD, Dufies M, Giuliano S, Douguet L, Grépin R, Durivault J, Lenormand P, Glisse N, Mintcheva J, Vouret-Craviari V, Mograbi B, Wurmser M, Ambrosetti D, Rioux-Leclercq N, Maire P, Pagès G.

    Theranostics. 2019 Jan 21;9(3):661-675.

    PMID: 30809300

  • PD1/PD-L1 inhibitor treatment for late stage non-small cell lung carcinoma, sometimes…does more harm than good!

    Hofman P.

    J Thorac Dis. 2019 Mar;11(Suppl 3):S396-S398. doi: 10.21037/jtd.2018.11.140. No abstract available.

    PMID: 30997230

  • Are There New Biomarkers in Tissue and Liquid Biopsies for the Early Detection of Non-Small Cell Lung Cancer?

    Calabrese F, Lunardi F, Pezzuto F, Fortarezza F, Vuljan SE, Marquette C, Hofman P.

    J Clin Med. 2019 Mar 26;8(3). pii: E414. doi: 10.3390/jcm8030414. Review.

    PMID: 30917582

  • In-house Implementation of Tumor Mutational Burden Testing to Predict Durable Clinical Benefit in Non-small Cell Lung Cancer and Melanoma Patients.

    Heeke S, Benzaquen J, Long-Mira E, Audelan B, Lespinet V, Bordone O, Lalvée S, Zahaf K, Poudenx M, Humbert O, Montaudié H, Dugourd PM, Chassang M, Passeron T, Delingette H, Marquette CH, Hofman V, Stenzinger A, Ilié M, Hofman P.

    Cancers (Basel). 2019 Aug 29;11(9). pii: E1271. doi: 10.3390/cancers11091271.

    PMID: 31470674



  • Recent advances in the molecular landscape of lung neuroendocrine tumors.

    Pelosi G, Bianchi F, Hofman P, Pattini L, Ströbel P, Calabrese F, Naheed S, Holden C, Cave J, Bohnenberger H, Dinter H, Harari S, Albini A, Sonzogni A, Papotti M, Volante M, Ottensmeier CH.

    Expert Rev Mol Diagn. 2019 Apr;19(4):281-297. doi: 10.1080/14737159.2019.1595593. Epub 2019 Mar 27.

    PMID: 30900485

  • EGFR Mutation Analysis in Non-small Cell Lung Carcinoma from Tissue Samples Using the Fully Automated Idylla™ qPCR System.

    Heeke S, Hofman P. 

    Methods Mol Biol. 2019;2054:147‐155.


    PMID: 31482454

  • Recent advances in the molecular landscape of lung neuroendocrine tumors

    Pelosi G, Bianchi F, Hofman P, Pattini L, Ströbel P, Calabrese F, Naheed S, Holden C, Cave J, Bohnenberger H, Dinter H, Harari S, Albini A, Sonzogni A, Papotti M, Volante M, Ottensmeier CH.
    Expert Rev Mol Diagn. 2019 Apr;19(4):281-297. doi: 10.1080/14737159.2019.1595593. Epub 2019 Mar 27. Review.
    PMID: 30900485

  • Germinal immunogenetics as a predictive factor for immunotherapy.

    Refae S, Gal J, Brest P, Milano G.

    Crit Rev Oncol Hematol. 2019 Sep;141:146-152. doi: 10.1016/j.critrevonc.2019.06.013. Epub 2019 Jun 28. Review.

    PMID: 31301542

  • The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress.

    Moreno Leon L, Gautier M, Allan R, Ilié M, Nottet N, Pons N, Paquet A, Lebrigand K, Truchi M, Fassy J, Magnone V, Kinnebrew G, Radovich M, Cheok MH, Barbry P, Vassaux G, Marquette CH, Ponzio G, Ivan M, Pottier N, Hofman P, Mari B, Rezzonico R.

    Oncogene. 2019 Nov;38(46):7146-7165. doi: 10.1038/s41388-019-0935-y. Epub 2019 Aug 15.

    PMID: 31417181

  • First-line immunotherapy for patients with advanced stage or metastatic non-small cell lung cancer…finally what threshold of PD-L1 expression on tumor cells?

    Hofman P.

    Transl Lung Cancer Res. 2019 Oct;8(5):728-730. doi: 10.21037/tlcr.2019.04.18. No abstract available.

    PMID: 31737511

  • Liquid biopsy in the era of immuno-oncology: is it ready for prime-time use for cancer patients?

    Hofman P, Heeke S, Alix-Panabières C, Pantel K.

    Ann Oncol. 2019 Sep 1;30(9):1448-1459. doi: 10.1093/annonc/mdz196.

    PMID:  31228184

  • GC content shapes mRNA storage and decay in human cells.

    Courel M, Clément Y, Bossevain C, Foretek D, Vidal Cruchez O, Yi Z, Bénard M, Benassy MN, Kress M, Vindry C, Ernoult-Lange M, Antoniewski C, Morillon A, Brest P, Hubstenberger A, Roest Crollius H, Standart N, Weil D.

    Elife. 2019 Dec 19;8. pii: e49708. doi: 10.7554/eLife.49708.

    PMID: 31855182

  • Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids.

    Alcala N, Leblay N, Gabriel AAG, Mangiante L, Hervas D, Giffon T, Sertier AS, Ferrari A, Derks J, Ghantous A, Delhomme TM, Chabrier A, Cuenin C, Abedi-Ardekani B, Boland A, Olaso R, Meyer V, Altmuller J, Le Calvez-Kelm F, Durand G, Voegele C, Boyault S, Moonen L, Lemaitre N, Lorimier P, Toffart AC, Soltermann A, Clement JH, Saenger J, Field JK, Brevet M, Blanc-Fournier C, Galateau-Salle F, Le Stang N, Russell PA, Wright G, Sozzi G, Pastorino U, Lacomme S, Vignaud JM, Hofman V, Hofman P, Brustugun OT, Lund-Iversen M, Thomas de Montpreville V, Muscarella LA, Graziano P, Popper H, Stojsic J, Deleuze JF, Herceg Z, Viari A, Nuernberg P, Pelosi G, Dingemans AMC, Milione M, Roz L, Brcic L, Volante M, Papotti MG, Caux C, Sandoval J, Hernandez-Vargas H, Brambilla E, Speel EJM, Girard N, Lantuejoul S, McKay JD, Foll M, Fernandez-Cuesta L.

    Nat Commun. 2019 Aug 20;10(1):3407. doi: 10.1038/s41467-019-11276-9.

    PMID: 31431620

  • The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis.

    Savary G, Dewaeles E, Diazzi S, Buscot M, Nottet N, Fassy J, Courcot E, Henaoui IS, Lemaire J, Martis N, Van der Hauwaert C, Pons N, Magnone V, Leroy S, Hofman V, Plantier L, Lebrigand K, Paquet A, Lino Cardenas CL, Vassaux G, Hofman P, Günther A, Crestani B, Wallaert B, Rezzonico R, Brousseau T, Glowacki F, Bellusci S, Perrais M, Broly F, Barbry P, Marquette CH, Cauffiez C, Mari B, Pottier N.

    Am J Respir Crit Care Med. 2019 Jul 15;200(2):184-198. doi: 10.1164/rccm.201807-1237OC.

    PMID: 30964696

  • Never Travel Alone: The Crosstalk of Circulating Tumor Cells and the Blood Microenvironment.

    Heeke S, Mograbi B, Alix-Panabières C, Hofman P.

    Cells. 2019 Jul 13;8(7). pii: E714. doi: 10.3390/cells8070714. Review.

    PMID: 31337010

  • Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy. (Correction)

    Fumet JD, Richard C, Ledys F, Klopfenstein Q, Joubert P, Routy B, Truntzer C, Gagné A, Hamel MA, Guimaraes CF, Coudert B, Arnould L, Favier L, Lagrange A, Ladoire S, Saintigny P, Ortiz-Cuaran S, Perol M, Foucher P, Hofman P, Ilie M, Chevrier S, Boidot R, Derangere V, Ghiringhelli F.

    Br J Cancer. 2019 Jul;121(3):283. doi: 10.1038/s41416-019-0512-8.

    PMID: 31235866

  • Alternative splicing of P2RX7 pre-messenger RNA in health and diseases: Myth or reality?

    Benzaquen J, Heeke S, Janho Dit Hreich S, Douguet L, Marquette CH, Hofman P, Vouret-Craviari V.

    Biomed J. 2019 Jun;42(3):141-154. doi: 10.1016/ Epub 2019 Jul 15. Review.

    PMID: 31466708

  • Companion diagnostic tests for treatment of lung cancer patients: what are the current and future challenges?

    Hofman P, Barlesi F.

    Expert Rev Mol Diagn. 2019 May;19(5):429-438. doi: 10.1080/14737159.2019.1611426. Epub 2019 May 6.

    PMID: 31018102

  • Toward precision medicine based on the molecular landscape of carcinoma in situ of the bronchus: is it realistic for patients with pre-invasive lung disease?

    Hofman P.

    J Thorac Dis. 2019 May;11(Suppl 9):S1286-S1288. doi: 10.21037/jtd.2019.04.87. No abstract available.

    PMID: 31245111

  • DNAshell Protects DNA Stored at Room Temperature for Downstream Next-Generation Sequencing Studies.

    Washetine K, Heeke S, Ribeyre C, Bourreau C, Normand C, Blons H, Laurent-Puig P, Mulot C, Clermont D, David M, Clément B, Dagher G, Hofman P.

    Biopreserv Biobank. 2019 Aug;17(4):352-354. doi: 10.1089/bio.2018.0129. Epub 2019 Mar 26. No abstract available.

    PMID: 30912674

  • Tumor banks and complex data management: Current and future challenges.

    Hofman P, Dagher G, Laurent-Puig P, Marquette CH, Barlesi F, Bibeau F, Clément B.

    Ann Pathol. 2019 Apr;39(2):137-143. doi: 10.1016/j.annpat.2019.01.017. Epub 2019 Feb 25. Review. French.

    PMID: 30819623

  • Single-cell genetic analysis validates cytopathological identification of circulating cancer cells in patients with clear cell renal cell carcinoma.

    Broncy L, Njima BB, Méjean A, Béroud C, Romdhane KB, Ilie M, Hofman V, Muret  J, Hofman P, Bouhamed HC, Paterlini-Bréchot AP.

    Oncotarget. 2018 Apr 13;9(28):20058-20074. 

    doi: 10.18632/oncotarget.25102. eCollection 2018 Apr 13.

    PMID: 29732003;

    PubMed Central PMCID: PMC5929446.

  • Multi-laboratory proficiency testing of clinical cancer genomic profiling by next-generation sequencing.

    Zhong Q, Wagner U, Kurt H, Molinari F, Cathomas G, Komminoth P, Barman-Aksözen J, Schneider-Yin X, Rey JP, Vassella E, Rogel U, Diebold J, McKee  T, Jochum W, Kashofer K, Hofman P, Zischka M, Moch H, Rechsteiner M, Wild PJ.

    Pathol Res Pract. 2018 Jul;214(7):957-963.

    doi: 10.1016/j.prp.2018.05.020. Epub 2018 May 22.

    PMID: 29807778.

  • [Focus on clinical and pathological management of conjunctival melanocytic tumors].

    Lassalle S, Caujolle JP, Leger F, Maschi C, Gastaud L, Nahon-Esteve S, Thariat J, Baillif S, Hofman P.

    Ann Pathol. 2018 Jun;38(3):153-163.

    doi: 10.1016/j.annpat.2018.03.006. Epub 2018 May 24. Review. French.

    PMID: 29803361.

  • E2F1 inhibition mediates cell death of metastatic melanoma.

    Rouaud F, Hamouda-Tekaya N, Cerezo M, Abbe P, Zangari J, Hofman V, Ohanna M,  Mograbi B, El-Hachem N, Benfodda Z, Lebeau A, Tulic MK, Hofman P, Bertolotto C, Passeron T, Annicotte JS, Ballotti R, Rocchi S.

    Cell Death Dis. 2018 May 1;9(5):527.

    doi: 10.1038/s41419-018-0566-1.

    PMID: 29743521;

    PubMed Central PMCID: PMC5943238.

  • Use of the 22C3 anti-programmed death-ligand 1 antibody to determine programmed death-ligand 1 expression in cytology samples obtained from non-small cell lung cancer patients.

    Ilie M, Juco J, Huang L, Hofman V, Khambata-Ford S, Hofman P.

    Cancer Cytopathol. 2018 Apr;126(4):264-274.

    doi: 10.1002/cncy.21977. Epub 2018 Feb 7.

    PMID: 29411536.


  • Rapid decay  of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition.

    Zangari J, Ilie M, Rouaud F, Signetti L, Ohanna M, Didier R, Roméo B, Goldoni D, Nottet N, Staedel C, Gal J, Mari B, Mograbi B, Hofman P, Brest P.

    Nucleic Acids Res. 2018 Apr 20;46(7):3813-3814.

    doi: 10.1093/nar/gky213.

    PMID: 29562367;

    PubMed Central PMCID: PMC5909457.

  • Use of the Ion PGM and the GeneReader NGS Systems in Daily Routine Practice for Advanced Lung Adenocarcinoma Patients: A Practical Point of View Reporting a  Comparative Study and Assessment of 90 Patients.

    Heeke S, Hofman V, Long-Mira E, Lespinet V, Lalvée S, Bordone O, Ribeyre C, Tanga V, Benzaquen J, Leroy S, Cohen C, Mouroux J, Marquette CH, Ilié M, Hofman P.

    Cancers (Basel). 2018 Mar 21;10(4). pii: E88.

    doi: 10.3390/cancers10040088.

    PMID: 29561830;

    PubMed Central PMCID: PMC5923343.

  • Any Place for Immunohistochemistry  within the Predictive Biomarkers of Treatment in Lung Cancer Patients?

    Hofman V, Lassalle S, Bence C, Long-Mira E, Nahon-Estève S, Heeke S, Lespinet-Fabre V, Butori C, Ilié M, Hofman P.

    Cancers (Basel). 2018 Mar 13;10(3). pii: E70.

    doi: 10.3390/cancers10030070. Review.

    PMID: 29534030;

    PubMed Central PMCID: PMC5876645.

  • Use of circulating tumor cells in prospective clinical trials for  NSCLC patients - standardization of the pre-analytical conditions.

    Ilie M, Hofman V, Leroy S, Cohen C, Heeke S, Cattet F, Bence C, Lalvée S, Mouroux J, Marquette CH, Hofman P; STALKLUNG01 and AIR Study Consortium Investigators.

    Clin Chem Lab  Med. 2018 May 24;56(6):980-989.

    doi: 10.1515/cclm-2017-0764.

    PMID: 29397019.

  • Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA.

    Washetine K, Kara-Borni M, Heeke S, Bonnetaud C, Félix JM, Ribeyre L, Bence C, Ilié M, Bordone O, Pedro M, Maitre P, Tanga V, Gormally E, Mossuz P, Lorimier  P, Marquette CH, Mouroux J, Cohen C, Lassalle S, Long-Mira E, Clément B, Dagher G, Hofman V, Hofman P.

    Cancers (Basel). 2018  Jun 11;10(6). pii: E195.

    doi: 10.3390/cancers10060195.

    PMID: 29891792;

    PubMed Central PMCID: PMC6025404.

  • Effect of mutant variants of the KRAS gene on PD-L1 expression and on the immune microenvironment and association with clinical outcome in lung adenocarcinoma patients.

    Falk AT, Yazbeck N, Guibert N, Chamorey E, Paquet A, Ribeyre L, Bence C, Zahaf K, Leroy S, Marquette CH, Cohen C, Mograbi B, Mazières J, Hofman V, Brest P, Hofman P, Ilié M.

    Lung Cancer. 2018 Jul;121:70-75.

    doi: 10.1016/j.lungcan.2018.05.009. Epub 2018 May 26.

    PMID: 29858030.

  • Spotlight on tumor mutational burden in patients with non-small cell lung carcinoma.

    Ilie M, Hofman P.

    Transl Lung Cancer Res. 2018 Dec;7(6):614-615.

    doi: 10.21037/tlcr.2018.08.06.

    PMID: 30505705;

    PubMed Central PMCID: PMC6249616.

  • Establishing a Dedicated Lung Cancer Biobank at the University Center Hospital of Nice (France). Why and How?

    Washetine K, Heeke S, Bonnetaud C, Kara-Borni M, Ilié M, Lassalle S, Butori C, Long-Mira E, Marquette CH, Cohen C, Mouroux J, Selva E, Tanga V, Bence C, Félix JM, Gazoppi L, Skhiri T, Gormally E, Boucher P, Clément B, Dagher G, Hofman V, Hofman P.

    Cancers (Basel). 2018 Jun 29;10(7). pii: E220.

    doi: 10.3390/cancers10070220.

    PMID: 29966305;

    PubMed  Central PMCID: PMC6070810.

  • Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells.

    Grasset EM, Bertero T, Bozec A, Friard J, Bourget I, Pisano S, Lecacheur M, Maiel M, Bailleux C, Emelyanov A, Ilie M, Hofman P, Meneguzzi G, Duranton C, Bulavin DV, Gaggioli C.

    Cancer Res. 2018 Sep 15;78(18):5229-5242.

    doi: 10.1158/0008-5472.CAN-18-0601. Epub 2018 Jul 19.

    PMID: 30026329.

  • Chromogenic Multiplex Immunohistochemistry Reveals Modulation of the Immune Microenvironment Associated with Survival in Elderly Patients with Lung Adenocarcinoma.

    Ilié M, Beaulande M, Ben Hadj S, Chamorey E, Schiappa R, Long-Mira E, Lassalle S, Butori C, Cohen C, Leroy S, Guérin O, Mouroux J, Marquette CH, Pomerol JF, Erb G, Hofman V, Hofman P.

    Cancers (Basel). 2018 Sep 13;10(9). pii: E326.

    doi: 10.3390/cancers10090326.

    PMID: 30216999;

    PubMed Central PMCID: PMC6162494.

  • ALK IHC and FISH discordant results in patients with NSCLC and treatment response: for discussion  of the question-to treat or not to treat?

    Cabillic F, Hofman P, Ilie M, Peled N, Hochmair M, Dietel M, Von Laffert M, Gosney JR, Lopez-Rios F, Erb G, Schalles U, Barlesi F.

    ESMO Open. 2018 Sep 17;3(6):e000419.

    doi: 10.1136/esmoopen-2018-000419. eCollection 2018.

    PMID: 30245863;

    PubMed Central PMCID: PMC6144904.

  • Automated chromogenic multiplexed immunohistochemistry assay for diagnosis and predictive biomarker testing in non-small cell lung cancer.

    Ilie M, Beaulande M, Hamila M, Erb G, Hofman V, Hofman P.

    Lung Cancer. 2018 Oct;124:90-94.

    doi: 10.1016/j.lungcan.2018.07.037. Epub 2018 Jul 31.

    PMID: 30268486.

  • Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis.

    Smeele P, d'Almeida SM, Meiller C, Chéné AL, Liddell C, Cellerin L, Montagne  F, Deshayes S, Benziane S, Copin MC, Hofman P, Le Pimpec-Barthes F, Porte H, Scherpereel A, Grégoire M, Jean D, Blanquart C.

    Mol Cancer. 2018 Oct 11;17(1):148.

    doi: 10.1186/s12943-018-0891-0. 

    PMID: 30309369;

    PubMed Central PMCID: PMC6180566.

  • Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy.

    Fumet JD, Richard C, Ledys F, Klopfenstein Q, Joubert P, Routy B, Truntzer C, Gagné A, Hamel MA, Guimaraes CF, Coudert B, Arnould L, Favier L, Lagrange A, Ladoire S, Saintigny P, Ortiz-Cuaran S, Perol M, Foucher P, Hofman P, Ilie M, Chevrier S, Boidot R, Derangere V, Ghiringhelli F.

    Br J Cancer. 2018 Oct;119(8):950-960.

    doi: 10.1038/s41416-018-0220-9. Epub 2018 Oct 15.

    PMID: 30318514.

  • Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients.

    Ilié M, Ngo-Mai M, Long-Mira E, Lassalle S, Butori C, Bence C, Hamila M, Hofman V, Hofman P.

    J Vis Exp. 2018 Sep 25;(139).

    doi: 10.3791/58082.

    PMID: 30320751;

    PubMed Central PMCID: PMC6235290.

  • [Next generation biobanking: the challenge of data].

    Dagher G, Lavitrano ML, Hofman P.

    Med Sci (Paris). 2018 Oct;34(10):849-851.

    doi: 10.1051/medsci/2018203.  Epub 2018 Nov 19. French.

    PMID: 30451660.

  • Tumor mutational burden assessment as a predictive biomarker for immunotherapy in lung cancer patients: getting ready for prime-time or not?

    Heeke S, Hofman P.

    Transl Lung Cancer Res. 2018 Dec;7(6):631-638.

    doi: 10.21037/tlcr.2018.08.04. Review.

    PMID: 30505707;

    PubMed Central PMCID: PMC6249624.

  • Monitoring BRAF and NRAS mutations with cell-free circulating tumor DNA from metastatic melanoma patients.

    Long-Mira E, Ilie M, Chamorey E, Leduff-Blanc F, Montaudié H, Tanga V, Allégra M, Lespinet-Fabre V, Bordone O, Bonnetaud C, Schiappa R, Butori C, Bence C, Lacour JP, Hofman V, Hofman P.

    Oncotarget. 2018 Nov 16;9(90):36238-36249.

    doi: 10.18632/oncotarget.26343. eCollection 2018 Nov 16.

    PMID: 30546839;

    PubMed Central PMCID: PMC6281416.

  • [Practices in infectious pathology in France in 2015. Results of the national survey].

    Tauziède-Espariat A, Chrétien F, Jouvion G, Alde-Biassette H, Hofman P.

    Ann Pathol. 2018 Feb;38(1):55-63.

    doi: 10.1016/j.annpat.2017.12.002. Epub 2018 Jan 7. French.

    PMID: 29317100.

  • Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype.

    Ohanna M, Cerezo M, Nottet N, Bille K, Didier R, Beranger G, Mograbi B, Rocchi S, Yvan-Charvet L, Ballotti R, Bertolotto C.

    Genes Dev. 2018 Mar 1;32(5-6):448-461. doi: 10.1101/gad.305854.117. Epub 2018 Mar 22.

    PMID: 29567766;

    PubMed Central PMCID: PMC5900716.

  • Atezolizumab in advanced non-small cell lung cancer.

    Ilie M, Hofman P.

    J Thorac Dis. 2017 Oct;9(10):3603-3606.

    doi: 10.21037/jtd.2017.09.73.

    PMID: 29268352;

    PubMed Central PMCID: PMC5723868.

  • ALK Status Assessment with Liquid Biopsies of Lung Cancer Patients.

    Hofman P.

    Cancers (Basel). 2017 Aug 12;9(8). pii: E106.

    doi: 10.3390/cancers9080106. Review.

    PMID: 28805673;

    PubMed Central PMCID: PMC5575609.

  • Liquid biopsy in lung cancer.

    Mlika M, Hofman P, Dziri C, Mezni F.

    Tunis Med. 2017 Novembre;95(11):965-971.

    Pubmed PMID:

  • [PD1/PD-L1 immunohistochemistry in thoracic oncology: Where are we?].

    Hofman P, Ilié M, Lassalle S, Long E, Bence C, Butori C, Hofman V.

    Ann Pathol. 2017 Feb;37(1):39-45.

    doi: 10.1016/j.annpat.2016.12.006. Epub 2017 Jan 31. French. Erratum in: Ann Pathol. 2017 Aug;37(4):344.

    PMID: 28159404.

  • Pathology of infectious diseases: what does the future hold?

    Hofman P, Lucas S, Jouvion G, Tauziède-Espariat A, Chrétien F, Cathomas G.

    Virchows Arch. 2017  May;470(5):483-492.

    doi: 10.1007/s00428-017-2082-6. Epub 2017 Feb 10. Review.

    PMID: 28188440.

  • Expression of MET in circulating tumor cells correlates with expression in tumor tissue from advanced-stage lung cancer patients.

    Ilie M, Szafer-Glusman E, Hofman V, Long-Mira E, Suttmann R, Darbonne W, Butori C, Lalvée S, Fayada J, Selva E, Yu W, Marquette CH, Shames DS, Punnoose E, Hofman P.

    Oncotarget. 2017 Apr 18;8(16):26112-26121.

    doi: 10.18632/oncotarget.15345.

    PMID: 28212540;

    Pubmed Central PMCID: PMC5432243.

  • Inverted conjunctival papilloma: a certainly underestimated high-risk lesion for carcinomatous transformation-a case report.

    Lassalle S, Maschi C, Caujolle JP, Giordanengo V, Hofman P.

    Can J Ophthalmol. 2017 Feb;52(1):e30-e31.

    doi: 10.1016/j.jcjo.2016.08.003. Epub 2016 Nov 16.

    PMID: 28237169.


  • Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy.

    Roussel H, De Guillebon E, Biard L, Mandavit M, Gibault L, Fabre E, Antoine M, Hofman P, Beau-Faller M, Blons H, Danel C, Barthes FLP, Gey A, Granier C, Wislez M, Laurent-Puig P, Oudard S, Bruneval P, Badoual C, Cadranel J, Tartour E.

    Oncoimmunology. 2017 Feb 21;6(4):e1286437.

    doi: 10.1080/2162402X.2017.1286437. eCollection 2017.

    PMID: 28507793;

    PubMed Central PMCID: PMC5414864.

  • NGS analysis on tumor tissue and cfDNA for genotype-directed therapy in metastatic NSCLC patients. Between hope and hype?

    Falk AT, Heeke S, Hofman V, Lespinet V, Ribeyre C, Bordone O, Poudenx M, Otto J, Garnier G, Castelnau O, Guigay J, Leroy S, Marquette CH, Hofman P, Ilié M.

    Expert Rev Anticancer Ther. 2017 Aug;17(8):681-685.

    doi: 10.1080/14737140.2017.1331736. Epub 2017 May 22.

    PMID: 28511612.

  • Immunotherapy supplanting chemotherapy for upfront treatment of advanced non-small cell lung cancer: what's next?

    Ilie M, Hofman P.

    J Thorac Dis. 2017 May;9(5):E519-E521.

    doi: 10.21037/jtd.2017.03.155.

    PMID: 28616326;

    PubMed  Central PMCID: PMC5465171.

  • RECIST response and variation of circulating tumour cells in phase 1 trials: A prospective multicentric study.

    Massard C, Borget I, Farace F, Aspeslagh S, Le Deley MC, Le Tourneau C, Bidard FC, Pierga JY, Dieras V, Hofman P, Spano JP, Ferte C, Lacroix L, Soria JC.

    Eur J Cancer. 2017 Sep;83:185-193.

    doi: 10.1016/j.ejca.2017.05.016. Epub 2017 Jul 22.

    PMID: 28743036.

  • Erratum à l’article : « Immunohistochimie PD-1/PD-L1 en oncologie thoracique : où en sommes-nous ? »

    Hofman P, Ilié M, Lassalle S, Long É, Coraline Bence, Butori C, Hofman V.

    [Ann. Pathol. 37(1) (2017) 39–45]. Ann Pathol. 2017 Aug;37(4):344.

    doi: 10.1016/j.annpat.2017.06.002. Epub 2017 Aug 1. French.

    PMID: 28778623.

  • Use of the 22C3 anti-PD-L1 antibody to determine PD-L1 expression in multiple  automated immunohistochemistry platforms.

    Ilie M, Khambata-Ford S, Copie-Bergman C, Huang L, Juco J, Hofman V, Hofman P.

    PLoS One. 2017 Aug 10;12(8):e0183023.

    doi: 10.1371/journal.pone.0183023. eCollection 2017.

    Erratum in: PLoS One. 2017 Oct 13;12 (10 ):e0186537.

    PMID: 28797130;

    PubMed Central PMCID: PMC5552229.

  • ALK in Non-Small Cell Lung Cancer (NSCLC) Pathobiology, Epidemiology, Detection from Tumor Tissue and Algorithm Diagnosis in a Daily Practice.

    Hofman P.

    Cancers (Basel). 2017 Aug 12;9(8). pii: E107.

    doi: 10.3390/cancers9080107. Review.

    PMID: 28805682;

    PubMed Central PMCID: PMC5575610.

  • Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.

    Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D. 

    Sci Rep. 2017 Mar 15;7(1):195. doi:10.1038/s41598-017-00269-7.

    PMID: 28298645;

    PubMed Central PMCID: PMC5428028

  • MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma.

    Bozec A, Zangari J, Butori-Pepino M, Ilie M, Lalvee S, Juhel T, Butori C, Brest P, Hofman P, Vouret-Craviari V.

    Oncotarget. 2017 Jul 11;8(34):57174-57186.

    doi: 10.18632/oncotarget.19170. eCollection 2017 Aug 22.

    PMID: 28915663;

    PubMed Central PMCID: PMC5593634.

  • Training the Next Generation of Biobankers: A Two-Year Master's Course in the Management of Biobanks.

    Gormally E, Hardy I, Caboux E, di Donato JH, Hainaut P, Hofman P.

    Biopreserv Biobank. 2017 Oct;15(5):438-450.

    doi: 10.1089/bio.2017.0002. Epub 2017 Sep 18.

    PMID: 28922617.

  • Correction: Use of the 22C3 anti-PD-L1 antibody to determine PD-L1 expression  in multiple automated immunohistochemistry platforms.

    Ilie M, Khambata-Ford S, Copie-Bergman C, Huang L, Juco J, Hofman V, Hofman P.

    PLoS One. 2017 Oct 13;12(10):e0186537.

    doi: 10.1371/journal.pone.0186537. eCollection 2017.

    PMID: 29028832;

    PubMed Central PMCID: PMC5640228.

  • PD-L1 immunohistochemistry for non-small cell lung carcinoma: which strategy should be adopted?

    Hofman P.

    Expert Rev Mol Diagn. 2017 Dec;17(12):1097-1108.

    doi: 10.1080/14737159.2017.1398083. Epub 2017 Nov 1. Review.

    PMID: 29069958.

  • The liquid biopsy: a tool for a combined diagnostic and theranostic approach for care of a patient with late-stage lung carcinoma presenting with bilateral ocular metastases.

    Bouhlel L, Hofman V, Maschi C, Ilié M, Allégra M, Marquette CH, Audigier-Valette C, Thariat J, Hofman P.

    Expert Rev Anticancer Ther. 2017 Dec;17(12):1087-1092.

    doi: 10.1080/14737140.2017.1398089. Epub 2017 Nov 2.

    PMID: 29069959.

  • Liquid Biopsy and Therapeutic Targets: Present and Future Issues in Thoracic Oncology.

    Hofman P.

    Cancers (Basel). 2017 Nov 10;9(11). pii: E154.

    doi: 10.3390/cancers9110154. Review.

    PMID: 29125548;

    PubMed Central PMCID: PMC5704172.

  • Optimization of EGFR mutation detection by the fully-automated qPCR-based Idylla system on tumor tissue from patients with non-small cell lung cancer.

    Ilie M, Butori C, Lassalle S, Heeke S, Piton N, Sabourin JC, Tanga V, Washetine K, Long-Mira E, Maitre P, Yazbeck N, Bordone O, Lespinet V, Leroy S, Cohen C, Mouroux J, Marquette CH, Hofman V, Hofman P.

    Oncotarget. 2017 Oct 4;8(61):103055-103062.

    doi: 10.18632/oncotarget.21476. eCollection 2017 Nov 28.

    PMID: 29262544;

    PubMed Central PMCID: PMC5732710.

  • Circulating tumour cells as a potential screening tool for lung cancer (the AIR study): protocol of a prospective multicentre cohort study in France.

    Leroy S, Benzaquen J, Mazzetta A, Marchand-Adam S, Padovani B, Israel-Biet D, Pison C, Chanez P, Cadranel J, Mazières J, Jounieaux V, Cohen C, Hofman V, Ilie M, Hofman P, Marquette CH; AIR Project Study Group.

    BMJ Open. 2017 Dec 26;7(12):e018884.

    doi: 10.1136/bmjopen-2017-018884.

    PMID: 29282271;

    PubMed Central PMCID: PMC5770962.

  • Reproducibility of PD-L1 assessment in non-small cell lung  cancer-know your limits but never stop trying to exceed them.

    Ilie M, Hofman P.

    Transl Lung Cancer  Res. 2017 Dec;6(Suppl 1):S51-S54.

    doi: 10.21037/tlcr.2017.10.13.

    PMID: 29299411;

    PubMed Central PMCID: PMC5750161.

  • Liquid biopsy for early detection of lung cancer.

    Hofman P.

    Curr Opin Oncol.  2017 Jan;29(1):73-78. Review.

    PMID: 27906860.

  • Quality Matters: 2016 Annual Conference of the National Infrastructures for Biobanking.

    Doucet M, Becker KF, Björkman J, Bonnet J, Clément B, Daidone MG, Duyckaerts  C, Erb G, Haslacher H, Hofman P, Huppertz B, Junot C, Lundeberg J, Metspalu A, Lavitrano M, Litton JE, Moore HM, Morente M, Naimi BY, Oelmueller U, Ollier B, Parodi B, Ruan L, Stanta G, Turano P, Vaught J, Watson P, Wichmann HE, Yuille M,  Zaomi M, Zatloukal K, Dagher G.

    Biopreserv Biobank. 2017 Jun;15(3):270-276.

    doi: 10.1089/bio.2016.0053. Epub 2016 Dec 19.

    PMID: 27992240;

    Pubmed Central PMCID: PMC5586151.

  • Rapid decay  of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition.

    Zangari J, Ilie M, Rouaud F, Signetti L, Ohanna M, Didier R, Roméo B, Goldoni D, Nottet N, Staedel C, Gal J, Mari B, Mograbi B, Hofman P, Brest P.

    Nucleic Acids Res. 2017 Apr 20;45(7):4131-4141.

    doi: 10.1093/nar/gkw1284.

    PMID: 27994032;

    Pubmed Central PMCID: PMC5397191.

  • Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells.

    Duchemin-Pelletier E, Baulard M, Spreux E, Prioux M, Burute M, Mograbi B, Guyon L, Théry M, Cochet C, Filhol O. 

    Cancers (Basel). 2017 Aug 31;9(9). pii: E114. doi: 10.3390/cancers9090114.

    PubMed PMID: 28858215

  • Response to first line  chemotherapy regimen is associated with efficacy of nivolumab in non-small-cell lung cancer.

    Kaderbhai CG, Richard C, Fumet JD, Aarnink A, Ortiz-Cuaran S, Pérol M, Foucher P, Coudert B, Favier L, Lagrange A, Limagne E, Boidot R, Ladoire S, Poudenx M, Ilie M, Hofman P, Saintigny P, Ghiringhelli F.

    Oncoimmunology. 2017 Jun 16;6(9):e1339856.

    doi: 10.1080/2162402X.2017.1339856. eCollection 2017.

    PMID: 28932641;

    PubMed Central PMCID: PMC5599088.

  • Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome.

    Melis N, Rubera I, Cougnon M, Giraud S, Mograbi B, Belaid A, Pisani DF, Huber SM, Lacas-Gervais S, Fragaki K, Blondeau N, Vigne P, Frelin C, Hauet T, Duranton C, Tauc M.

    J Am Soc Nephrol. 2017 Mar;28(3):811-822. doi: 10.1681/ASN.2016010012. Epub 2016 Sep 9.

    PMID: 27612998;

    PubMed Central PMCID: PMC5328152.


  • Immunotherapy in Non-Small Cell Lung Cancer: Biological Principles and Future Opportunities.

    Ilie M, Benzaquen J, Hofman V, Lassalle S, Yazbeck N, Leroy S, Heeke S, Bence C, Mograbi B, Glaichenhaus N, Marquette CH, Hofman P.

    Curr Mol Med. 2017;17(8):527-540. doi: 10.2174/1566524018666180222114038.

    PubMed PMID: 29473504.

  • Rebuttal from Dr. Hofman and Dr. Ilié.

    Ilié M, Hofman P.

    Transl Lung Cancer  Res. 2016 Aug;5(4):428-9.

    doi: 10.21037/tlcr.2016.08.05.

    PMID: 27657908;

    PubMed Central PMCID: PMC5009090.

  • PD-L1 expression in basaloid squamous cell lung carcinoma: Relationship to PD-1(+) and CD8(+) tumor-infiltrating T cells and outcome.

    Ilie M, Falk AT, Butori C, Chamorey E, Bonnetaud C, Long E, Lassalle S, Zahaf K, Vénissac N, Mouroux J, Cohen C, Brambilla E, Marquette CH, Hofman V, Hofman P.

    Mod Pathol. 2016 Dec;29(12):1552-1564.

    doi: 10.1038/modpathol.2016.149. Epub 2016 Aug 26.

    PMID: 27562497.

  • Pathologists and liquid biopsies: to be or not to be?

    Hofman P, Popper HH.

    Virchows Arch. 2016 Dec;469(6):601-609. Epub 2016 Aug 23. Review.

    Pubmed PMID:

  • Comparative analysis of micro-RNAs in human papillomavirus-positive versus -negative oropharyngeal cancers.

    Mirghani H, Ugolin N, Ory C, Goislard M, Lefèvre M, Baulande S, Hofman P, Guily JL, Chevillard S, Lacave R.

    Head Neck. 2016 Nov;38(11):1634-1642.

    doi: 10.1002/hed.24487. Epub 2016 Apr 21.

    PMID: 27097597.

  • p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis.

    Brichkina A, Bertero T, Loh HM, Nguyen NT, Emelyanov A, Rigade S, Ilie M, Hofman P, Gaggioli C, Bulavin DV. 

    Genes Dev. 2016 Dec 1;30(23):2623-2636.

    doi: 10.1101/gad.290346.116.

    PMID: 28007785;

    Pubmed Central PMCID: PMC5204354.

  • Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.

    Cerezo M, Lehraiki A, Millet A, Rouaud F, Plaisant M, Jaune E, Botton T, Ronco C, Abbe P, Amdouni H, Passeron T, Hofman V, Mograbi B, Dabert-Gay AS, Debayle D, Alcor D, Rabhi N, Annicotte JS, Héliot L, Gonzalez-Pisfil M, Robert C, Moréra S, Vigouroux A, Gual P, Ali MMU, Bertolotto C, Hofman P, Ballotti R, Benhida R, Rocchi S.

    Cancer Cell. 2016 Jul 11;30(1):183.

    doi:  10.1016/j.ccell.2016.06.007. Epub 2016 Jul 11.

    PMID: 27479035.

  • BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice.

    Hamouda MA, Jacquel A, Robert G, Puissant A, Richez V, Cassel R, Fenouille N, Roulland S, Gilleron J, Griessinger E, Dubois A, Bailly-Maitre B, Goncalves D, Mallavialle A, Colosetti P, Marchetti S, Amiot M, Gomez-Bougie P, Rochet N, Deckert M, Avet-Loiseau H, Hofman P, Karsenti JM, Jeandel PY, Blin-Wakkach C, Nadel B, Cluzeau T, Anderson KC, Fuzibet JG, Auberger P, Luciano F.

    J Exp Med. 2016 Aug 22;213(9):1705-22.

    doi: 10.1084/jem.20150983. Epub 2016 Jul 25.

    PMID: 27455953;

    Pubmed Central PMCID: PMC4995074.

  • A case report of isolated lymphadenopathy revealing localized leishmanial lymphadenopathy in an asthenic 25-year-old man.

    Hurlot Q, Fillaux J, Laurent C, Berry A, Hofman P, Marchou B, Delobel P, Brousset P, Martin-Blondel G.

    Medicine (Baltimore). 2016 Jul;95(29):e3932.

    doi: 10.1097/MD.0000000000003932.

    PMID: 27442631;

    Pubmed Central PMCID: PMC5265748.


  • [Standard of care of carcinomas on cancer of unknown primary site in 2016].

    Benderra MA, Ilié M, Hofman P, Massard C.

    Bull Cancer. 2016 Jul-Aug;103(7-8):697-705.

    doi: 10.1016/j.bulcan.2016.05.003. Epub 2016 Jun 29. French.

    PMID: 27372228.

  • Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.

    Corcelle-Termeau E, Vindeløv SD, Hämälistö S, Mograbi B, Keldsbo A, Bräsen JH, Favaro E, Adam D, Szyniarowski P, Hofman P, Krautwald S, Farkas T, Petersen NH, Rohde M, Linkermann A, Jäättelä M.

    Autophagy. 2016 May 3;12(5):833-49.

    doi: 10.1080/15548627.2016.1159378. Epub 2016 Apr 12.

    PMID: 27070082;

    Pubmed Central PMCID: PMC4854555.

  • MicroRNA-375/SEC23A as biomarkers of the in vitro efficacy of vandetanib.

    Lassalle S, Zangari J, Popa A, Ilie M, Hofman V, Long E, Patey M, Tissier F, Belléannée G, Trouette H, Catargi B, Peyrottes I, Sadoul JL, Bordone O, Bonnetaud C, Butori C, Bozec A, Guevara N, Santini J, Hénaoui IS, Lemaire G, Blanck O, Vielh P, Barbry P, Mari B, Brest P, Hofman P.

    Oncotarget. 2016 May 24;7(21):30461-78.

    doi: 10.18632/oncotarget.8458.

    PMID: 27036030;

    Pubmed Central PMCID: PMC5058693.

  • RNA Activation of the Vascular Endothelial Growth Factor Gene (VEGF) Promoter by Double-Stranded RNA and Hypoxia: Role of Noncoding VEGF Promoter Transcripts.

    Lopez P, Wagner KD, Hofman P, Van Obberghen E.

    Mol Cell Biol. 2016 May 2;36(10):1480-93.

    doi: 10.1128/MCB.01096-15. Print 2016 May 15.

    PMID: 26976645;

    Pubmed Central PMCID: PMC4859685.

  • High expression of TRF2, SOX10, and CD10 in circulating tumor microemboli detected in metastatic melanoma patients. A potential impact for the  assessment of disease aggressiveness.

    Long E, Ilie M, Bence C, Butori C, Selva E, Lalvée S, Bonnetaud C, Poissonnet G, Lacour JP, Bahadoran P, Brest P, Gilson E, Ballotti R, Hofman V, Hofman P.

    Cancer Med. 2016 Jun;5(6):1022-30.

    doi: 10.1002/cam4.661. Epub 2016 Mar 6.

    PMID: 26945789;

    Pubmed Central PMCID: PMC4924359.

  •  [Issues and current limits for immunohistochemical assessment of PD-L1 status in bronchial biopsies].

    Hofman V, Ilie M, Long E, Butori C, Lassalle S, Washetine K, Lalve S, Marquette CH, Soria JC, Hofman P.

    Bull Cancer. 2016 Apr;103(4):368-80.

    doi: 10.1016/j.bulcan.2016.01.014. Epub 2016 Feb  23. Review. French.

    PMID: 26920041.

  • Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients.

    Ilie M, Hofman V, Dietel M, Soria JC, Hofman P.

    Virchows Arch. 2016 May;468(5):511-25.

    doi: 10.1007/s00428-016-1910-4. Epub 2016 Feb 25. Review.

    PMID: 26915032.

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

    Klionsky DJ, … E, Belaid A, …, Brest P, …,  Hofman P, …, Mograbi B, …, Vouret-Craviari V, et al.

    Autophagy. 2016;12(1):1-222.

    doi: 10.1080/15548627.2015.1100356. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban].

    PMID: 26799652;

    Pubmed Central PMCID: PMC4835977.

  • Three Rounds of External Quality Assessment in France to Evaluate the Performance of 28 Platforms for Multiparametric Molecular Testing in Metastatic Colorectal and Non-Small Cell Lung Cancer.

    Dequeker EM, Keppens C, Egele C, Delen S, Lamy A, Lemoine A, Sabourin JC, Andrieu C, Ligtenberg M, Fetique D, Tops B, Descarpentries C, Blons H, Denoux Y,  Aube C, Penault-Llorca F, Hofman P, Leroy K, Le Marechal C, Doucet L, Duranton-Tanneur V, Pedeutour F, Soubeyran I, Côté JF, Emile JF, Vignaud JM, Monhoven N, Haddad V, Laurent-Puig P, van Krieken H, Nowak F, Lonchamp E, Bellocq JP, Rouleau E.

    J Mol Diagn. 2016 Mar;18(2):205-14.

    doi: 10.1016/j.jmoldx.2015.09.004. Epub 2016 Jan 2.

    PMID: 26752307.

  • Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation.

    Agus A, Denizot J, Thévenot J, Martinez-Medina M, Massier S, Sauvanet P, Bernalier-Donadille A, Denis S, Hofman P, Bonnet R, Billard E, Barnich N.

    Sci Rep. 2016 Jan 8;6:19032.

    doi: 10.1038/srep19032.

    PMID: 26742586;

    Pubmed Central PMCID: PMC4705701.

  • Detection and characterization of circulating  tumor cells in lung cancer: Why and how?

    Hofman VJ, Ilie M, Hofman PM.

    Cancer Cytopathol. 2016 Jun;124(6):380-7.

    doi: 10.1002/cncy.21651. Epub 2015 Nov 20.

    PMID: 26587794.

  • The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival.

    Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D.

    Sci Rep. 2016 Aug 4; 6:30776. doi: 10.1038/srep30776.

    PMID: 27488617; PubMed Central PMCID: PMC4973274.

  • Pros: Can tissue biopsy be replaced by liquid biopsy?

    Ilié M, Hofman P.

    Transl Lung Cancer Res. 2016 Aug;5(4):420-3.

    doi: 10.21037/tlcr.2016.08.06.

    PMID: 27655109;

    Pubmed Central PMCID: PMC5009092.

  • KRAS Mutations in Lung Adenocarcinoma: Molecular and Epidemiological Characteristics, Methods for Detection, and Therapeutic Strategy Perspectives.

    Guibert N, Ilie M, Long E, Hofman V, Bouhlel L, Brest P, Mograbi B, Marquette CH, Didier A, Mazieres J, Hofman P.

    Curr Mol Med. 2015;15(5):418-32. Review.

    PMID: 25941815.

  • Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux.

    Giuliano S, Cormerais Y, Dufies M, Grépin R, Colosetti P, Belaid A, Parola J, Martin A, Lacas-Gervais S, Mazure NM, Benhida R, Auberger P, Mograbi B, Pagès G.

    Autophagy. 2015 ;11(10):1891-904. doi: 10.1080/15548627.2015.1085742.

    PMID: 26312386; PubMed Central PMCID: PMC4824581.

  • Autophagy : Moving Benchside Promises to Patient Bedsides.

    Belaid A, Ndiaye PD, Filippakis H, Roux J, Röttinger É, Graba Y, Brest P, Hofman P, Mograbi B.

    Curr Cancer Drug Targets. 2015;15(8):684-702. Review.

    PMID: 26452384.

  • Sense and nonsense in the process of accreditation of a pathology laboratory.

    Long-Mira E, Washetine K, Hofman P.

    Virchows Arch. 2016 Jan;468(1):43-9.

    doi: 10.1007/s00428-015-1837-1. Epub 2015 Sep 3. Review.

    PMID: 26334197.

  • Stratification of resectable lung adenocarcinoma by molecular and pathological risk estimators.

    Rakha E, Pajares MJ, Ilie M, Pio R, Echeveste J, Hughes E, Soomro I, Long E, Idoate MA, Wagner S, Lanchbury JS, Baldwin DR, Hofman P, Montuenga LM.

    Eur J Cancer. 2015 Sep;51(14):1897-903.

    doi: 10.1016/j.ejca.2015.07.015. Epub 2015 Jul 30.

    PMID: 26235745.

  • French multicentric validation of ALK rearrangement diagnostic in 547 lung adenocarcinomas.

    Lantuejoul S, Rouquette I, Blons H, Le Stang N, Ilie M, Begueret H, Grégoire V, Hofman P, Gros A, Garcia S, Monhoven N, Devouassoux-Shisheboran M, Mansuet-Lupo A, Thivolet F, Antoine M, Vignaud JM, Penault-Llorca F, Galateau-Sallé F, McLeer-Florin A.

    Eur Respir J. 2015 Jul;46(1):207-18.

    doi: 10.1183/09031936.00119914. Epub 2015 Apr 30.

    PMID: 25929957.

  • Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer.

    Hofman P, Cherfils-Vicini J, Bazin M, Ilie M, Juhel T, Hébuterne X, Gilson E, Schmid-Alliana A, Boyer O, Adriouch S, Vouret-Craviari V.

    Cancer Res. 2015 Mar 1;75(5):835-45.

    doi: 10.1158/0008-5472.CAN-14-1778.  Epub 2015 Jan 6.

    PMID: 25564520.

  • Diet-induced hypoxia responsive element demethylation increases CEACAM6 expression, favouring Crohn's disease-associated Escherichia coli colonisation.

    Denizot J, Desrichard A, Agus A, Uhrhammer N, Dreux N, Vouret-Craviari V, Hofman P, Darfeuille-Michaud A, Barnich N.

    Gut. 2015 Mar;64(3):428-37.

    doi: 10.1136/gutjnl-2014-306944. Epub 2014 Jun 4.

    PMID: 24898815.

  • Immunohistochemistry as a potential tool for routine detection of the NRAS Q61R mutation in patients with metastatic melanoma.

    Ilie M, Long-Mira E, Funck-Brentano E, Lassalle S, Butori C, Lespinet-Fabre  V, Bordone O, Gay A, Zahaf K, Poissonnet G, Lacour JP, Bahadoran P, Ballotti R, Gros A, Dutriaux C, Saiag P, Merlio JP, Vergier B, Emile JF, Hofman V, Hofman P. 

    J Am Acad Dermatol. 2015 May;72(5):786-93.

    doi: 10.1016/j.jaad.2015.01.012. Epub 2015 Feb 7.

    PMID: 25659223.

  • Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia.

    Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu  M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM.

    Mol Cell Biol. 2015 May;35(9):1491-505.

    doi: 10.1128/MCB.01402-14. Epub 2015 Feb 17.

    PMID: 25691661;

    Pubmed Central PMCID: PMC4387213.

  • Autophagy and SQSTM1 on the RHOA(d) again: emerging roles of autophagy in the degradation of signaling proteins

    Belaid A, Ndiaye PD, Cerezo M, Cailleteau L, Brest P, Klionsky DJ, Carle GF, Hofman P, Mograbi B

    Autophagy. 2014 Feb;10(2):201-8

    PMID: 24300375

  • A new KIT mutation (N505I) in acral melanoma confers constitutive signaling, favors tumorigenic properties, and is sensitive to imatinib

    Allegra M, Giacchero D, Segalen C, Dumaz N, Butori C, Hofman V, Hofman P, Lacour JP, Bertolotto C, Bahadoran P, Ballotti R

    J Invest Dermatol. 2014 May;134(5):1473-1476.

    PMID: 24317392

  • Public-private relationships in biobanking: a still underestimated key component of open innovation

    Hofman P, Bréchot C, Zatloukal K, Dagher G, Clément B

    Virchows Arch. 2014 Jan;464(1):3-9.

    PMID: 24337181

  • Diagnostic value of immunohistochemistry for the detection of the BRAF(V600E) mutation in papillary thyroid carcinoma: comparative analysis with three DNA-based assays

    Ilie MI, Lassalle S, Long-Mira E, Bonnetaud C, Bordone O, Lespinet V, Lamy A, Sabourin JC, Haudebourg J, Butori C, Guevara N, Peyrottes I, Sadoul JL, Bozec  A, Santini J, Capper D, von Deimling A, Emile JF, Hofman V, Hofman P.

    Thyroid. 2014 May;24(5):858-66

    PMID: 24417277

  • Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition.

    de Reyniès A, Jaurand MC, Renier A, Couchy G, Hysi I, Elarouci N, Galateau-Sallé F, Copin MC, Hofman P, Cazes A, Andujar P, Imbeaud S, Petel F, Pairon JC, Le Pimpec-Barthes F, Zucman-Rossi J, Jean D.

    Clin Cancer Res. 2014 Mar 1;20(5):1323-34

    PMID: 24798160

  • BRAFV600E mutation analysis by immunohistochemistry in patients with thoracic metastases from colorectal cancer

    Ilie MI, Long-Mira E, Hofman V, Mouroux J, Vignaud JM, Gauchotte G, Begueret H, Merlio JP, Emile JF, Hébuterne X, Hofman P

    Pathology. 2014 Jun;46(4):311-5

    PMID: 24798160

  • LIF mediates proinvasive activation of stromal fibroblasts in cancer

    Albrengues J, Bourget I, Pons C, Butet V, Hofman P, Tartare-Deckert S, Feral CC, Meneguzzi G, Gaggioli C.

    Cell Rep. 2014 Jun 12;7(5):1664-1678

    PMID: 24857661

  • Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata.

    Castela E, Le Duff F, Butori C, Ticchioni M, Hofman P, Bahadoran P, Lacour JP, Passeron T.

    JAMA Dermatol. 2014 Jul;150(7):748-51

    PMID: 24872229

  • What place and what future for the pathology of infectious and tropical diseases in France?

    Hofman P

    Ann Pathol. 2014 Jun;34(3):171-82.

    PMID: 24950861

  • EFA6B antagonizes breast cancer

    Zangari J, Partisani M, Bertucci F, Milanini J, Bidaut G, Berruyer-Pouyet C, Finetti P, Long E, Brau F, Cabaud O, Chetaille B, Birnbaum D, Lopez M, Hofman P,  Franco M, Luton F.

    Cancer Res. 2014 Oct 1;74(19):5493-506

    PMID: 25115298.

  • A predictive transcriptomic signature of oropharyngeal cancer according to HPV16 status exclusively

    Mirghani H, Ugolin N, Ory C, Lefèvre M, Baulande S, Hofman P, St Guily JL, Chevillard S, Lacave R.

    Oral Oncol. 2014 Nov;50(11):1025-34

    PMID: 25156715

  • Sentinel" circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease

    Ilie M, Hofman V, Long-Mira E, Selva E, Vignaud JM, Padovani B, Mouroux J, Marquette CH, Hofman P.

    PLoS One.  2014 Oct 31;9(10):e111597

    PMID: 25360587

  • Constitutive activation of the renin-angiotensin system reduces visceral fat and improves glucose tolerance in mice

    Favre GA, Lebrun P, Lopez P, Butori C, Hofman P, Esnault VL, Van Obberghen E.

    J Renin Angiotensin Aldosterone Syst. 2014 Dec;15(4):396-409

    PMID: 25371094.

  • Immunohistochemistry and personalised medicine in lung oncology: advantages and limitations

    Hofman V, Ilie M, Long E, Lassalle S, Butori C, Bence C, Washetine K, Lalvee S, Hofman P.

    Bull Cancer. 2014 Oct;101(10):958-65

    PMID: 25373695


  • HIF1A regulates xenophagic degradation of adherent and invasive Escherichia coli (AIEC).

    Mimouna S, Bazin M, Mograbi B, Darfeuille-Michaud A, Brest P, Hofman P, Vouret-Craviari V.

    Autophagy. 2014;10(12):2333-45.

    PMID: 25484075

  • Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

    Ilie M, Hofman V, Long E, Bordone O, Selva E, Washetine K, Marquette CH, Hofman P.

    Ann Transl Med. 2014 Nov;2(11):107

    PMID: 25489581

  • Successful re-treatment of a relapsed V600E mutated HCL patient with low-dose vemurafenib

    C Bailleux, Robert G, Ginet C, Re D, Thyss A, Sudaka I, Peyrottes I, Hofman P, Auberger P, Peyrade F.

    Oncoscience. 2014 Dec 26;2(1):44-9. eCollection 2015.

    PMID: 25815361

  • Detection of circulating tumor cells from lung cancer patients in the era of targeted therapy: promises, drawbacks and pitfalls

    Hofman V, Ilie M, Long E, Guibert N, Selva E, Washetine K, Mograbi B, Mouroux J, Vénissac N, Reverso-Meinietti J, Milano G, Mazières J, Marquette CH, Paterlini-Bréchot P, Hofman P.

    Curr Mol Med. 2014 May;14(4):440-56. Review.

    PMID: 24730524

  • Detection of BRAF p.V600E Mutations in Melanoma by Immunohistochemistry Has a Good Interobserver Reproducibility

    Marin C, Beauchet A, Capper D, Zimmermann U, Julié C, Ilie M, Saiag P, von Deimling A, Hofman P, Emile JF.

    Arch Pathol Lab Med. 2014 Jan;138(1):71-5.

    PMID: 23651150

  • EU-US Expert Group on cost recovery in biobanks. Public biobanks: calculation and recovery of costs.

    Clément B, Yuille M, Zaltoukal K, Wichmann HE, Anton G, Parodi B, Kozera L, Bréchot C, Hofman P, Dagher G; EU-US Expert Group on cost recovery in biobanks.

    Sci Transl Med. 2014 Nov 5;6(261):261fs45

    PMID: 25378642.

  • Comparison of transcriptomic signature of post-Chernobyl and postradiotherapy thyroid tumors.

    Ory C, Ugolin N, Hofman P, Schlumberger M, Likhtarev IA, Chevillard S

    Thyroid. 2013 Nov;23(11):1390-400

    PMID: 23521174

  • Autophagy plays a critical role in the degradation of active RHOA, the control of cell cytokinesis, and genomic stability.

    Belaid A, Cerezo M, Chargui A, Corcelle-Termeau E, Pedeutour F, Giuliano S,  Ilie M, Rubera I, Tauc M, Barale S, Bertolotto C, Brest P, Vouret-Craviari V, Klionsky DJ, Carle GF, Hofman P, Mograbi B.

    Cancer Res. 2013 Jul 15;73(14):4311-22

    PMID: 23704209

  • Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma

    Bahadoran P, Allegra M, Le Duff F, Long-Mira E, Hofman P, Giacchero D, Passeron T, Lacour JP, Ballotti R.

    J Clin Oncol. 2013 Jul 1;31(19):e324-6

    PMID: 23715574

  • In papillary thyroid carcinoma, TIMP-1 expression correlates with BRAF (V600E) mutation status and together with hypoxia-related proteins predicts aggressive behavior

    Ilie MI, Lassalle S, Long-Mira E, Hofman V, Zangari J, Bénaim G, Bozec A, Guevara N, Haudebourg J, Birtwisle-Peyrottes I, Santini J, Brest P, Hofman P.

    Virchows Arch. 2013 Sep;463(3):437-44

    PMID: 23893334

  • Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients

    Ilie M, Hofman V, Zangari J, Chiche J, Mouroux J, Mazure NM, Pouysségur J, Brest P, Hofman P.

    Lung Cancer.  2013 Oct;82(1):16-23.

    PMID: 23910904

  • Measuring the contribution of tumor biobanks to research in oncology: surrogate indicators and bibliographic output

    Hofman V, Ilie M, Long E, Washetine K, Chabannon C, Figarella-Branger D, Clément B, Mabile L, Cambon-Thomsen A, Boucher P, Dagher G, Hewitt R, Parodi B, Hofman P.

    Biopreserv Biobank. 2013 Aug;11(4):235-44

    PMID: 24845591

  • Role of the surgical pathologist for tissue management in oncology

    Long É, Ilie M, Hofman V, Lassalle S, Butori C, AlsubaieS, Hofman P

    Bull Cancer. 2013 Sep;100(9):837-45

    PMID: 23985751

  • Acute kidney injury following crizotinib administration for non-small-cell lung carcinoma

    Gastaud L, Ambrosetti D, Otto J, Marquette CH, Coutts M, Hofman P, Esnault V, Favre G.

    Lung Cancer. 2013 Nov;82(2):362-4.

    PMID: 24001942

  • BRIF working group. Quantifying the use of bioresources for promoting their sharing in scientific research

    Mabile L, Dalgleish R, Thorisson GA, Deschênes M, Hewitt R, Carpenter J, Bravo E, Filocamo M, Gourraud PA, Harris JR, Hofman P, Kauffmann F, Muñoz-Fernàndez MA, Pasterk M, Cambon-Thomsen A

    Gigascience. 2013 May 1;2(1):7

    PMID: 23634721

  • Specificities of lung adenocarcinoma in women who have never smoked

    Mazières J, Rouquette I, Lepage B, Milia J, Brouchet L, Guibert N, Beau-Faller M, Validire P, Hofman P, Fouret P.

    J Thorac Oncol. 2013 Jul;8(7):923-9

    PMID: 23608817

  • Usefulness of immunocytochemistry for the detection of the BRAF(V600E) mutation in circulating tumor cells from metastatic melanoma patients.

    Hofman V, Ilie M, Long-Mira E, Giacchero D, Butori C, Dadone B, Selva E, Tanga V, Passeron T, Poissonnet G, Emile JF, Lacour JP, Bahadoran P, Hofman P.

    J Invest Dermatol.  2013 May;133(5):1378-81.

    doi: 10.1038/jid.2012.485. Epub 2013 Jan 10.

    PMID: 23303445

  • Setting up a department of molecular pathology in oncology in a pathology laboratory (LPCE, CHU de Nice).

    Long E, Hofman V, Ilie M, Lespinet V, Bonnetaud C, Bordone O, Gavric-Tanga V, Washetine K, Gaziello MC, Mauro V, Lassalle S, Selva E, Zahaf K, Santini J, Castillo L, Lacour JP, Vénissac N, Mouroux J, Otto J, Poudenx M, Marquette CH, Sabourin JC, Hofman P

    Ann Pathol. 2013 Feb;33(1):24-37

    PMID: 23472893

  • Accreditation of the activity of molecular pathology according to ISO 15189: key steps to follow and the main potential pitfalls

    Long E, Hofman V, Ilie M, Washetine K, Lespinet V, Bonnetaud C, Bordone O, Gavric-Tanga V, Gaziello MC, Lassalle S, Selva E, Zahaf K, Lamy A, Sabourin JC, Hofman P

    Ann Pathol. 2013 Feb;33(1):12-23

    PMID: 23472892

  • Noisy silent polymorphisms

    Korzeniewski S, Hofman P, Brest P

    Med Sci (Paris). 2013 Feb;29(2):124-6

    PMID: 23452592

  • Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma

    Bozec A, Ilie M, Dassonville O, Long E, Poissonnet G, Santini J, Chamorey E, Ettaiche M, Chauvière D, Peyrade F, Hebert C, Benezery K, Sudaka A, Haudebourg J, Selva E, Hofman P

    Eur Arch Otorhinolaryngol. 2013 Sep;270(10):2745-9.

    PMID: 23430081.

  • Significance of circulating tumor cell detection using the CellSearch system in patients with locally advanced head and neck squamous cell carcinoma.

    Bozec A, Ilie M, Dassonville O, Long E, Poissonnet G, Santini J, Chamorey E, Ettaiche M, Chauvière D, Peyrade F, Hebert C, Benezery K, Sudaka A, Haudebourg J, Selva E, Hofman P.

    Eur Arch Otorhinolaryngol. 2013 Sep;270(10):2745-9.

    doi: 10.1007/s00405-013-2399-y. Epub 2013 Feb 22.

    PMID: 23430081

  • Two panels of plasma microRNAs as non-invasive biomarkers for prediction of recurrence in resectable NSCLC. PLoS One. 2013;8(1):e54596.

    Sanfiorenzo C*, Ilie MI*, Belaid A, Barlési F, Mouroux J, Marquette CH, Brest P*, Hofman P*.

    doi: 10.1371/journal.pone.0054596. Epub 2013 Jan 16.

    PMID: 23342174


  • The accreditation of a surgical pathology and somatic genetic laboratory (LPCE, CHU of Nice) according to the ISO 15189 norm: Sharing of experience

    Washetine K, Long E, Hofman V, Lassalle S, Ilie M, Lespinet V, Bonnetaud C,  Bordone O, Gavric-Tanga V, Selva E, Reverso-Meinietti J, Sadoulet D, Lacour L, Bille Y, Lavagna R, Grier P, Zahaf K, Mari M, Hofman P

    Ann Pathol. 2013 Dec;33(6):386-97.

    PMID: 24331720

  • Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity.

    Rubera I, Duranton C, Melis N, Cougnon M, Mograbi B, Tauc M.

    Cell Death Dis. 2013 Oct 3;4: e817. doi: 10.1038/cddis.2013.355.

    PMID: 24091660

  • EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis.

    Vincent-Bugnas S, Vitale S, Mouline CC, Khaali W, Charbit Y, Mahler P, Prêcheur I, Hofman P, Maryanski JL, Doglio A

    PLoS One. 2013 Dec 19;8(12):e80336

    PMID: 24367478

  • BRAF EQA Group. Improvement of the quality of BRAF testing in melanomas with nationwide external quality assessment, for the BRAF EQA group

    Emile JF, Tisserand J, Bergougnoux L, Nowak F, Faucher G, Surel S, Lamy A, Lecorre D, Helias-Rodzewicz Z, Hofman P, Sabourin JC, Laurent-Puig P.

    BMC Cancer. 2013 Oct 11;13:472

    PMID: 24004837

  • Functional polymorphisms in the regulatory regions of the VNN1 gene are associated with susceptibility to inflammatory bowel diseases

    Gensollen T, Bourges C, Rihet P, Rostan A, Millet V, Noguchi T, Bourdon V, Sobol H, Dubuquoy L, Bertin B, Fumery M, Desreumaux P, Colombel JF, Chamaillard M, Hebuterne X, Hofman P, Naquet P, Galland F.

    Inflamm Bowel Dis. 2013 Oct;19(11):2315-25.

    PMID: 23949622

  • Signalphagy: scheduled signal termination by macroautophagy

    Belaid A, Ndiaye PD, Klionsky DJ, Hofman P, Mograbi B.

    Autophagy. 2013 Oct;9(10):1629-30

    PMID: 24004837

  • Guidelines for the use and interpretation of assays for monitoring autophagy.

    Klionsky DJ, …, Brest P, …, Hofman P, …, Mograbi B,…et al.

    Autophagy. 2012 Apr;8(4):445-544.

    PMID: 22966490


  • A comparative and integrative approach identifies ATPase family, AAA domain containing 2 as a likely driver of cell proliferation in lung adenocarcinoma.

    Fouret R, Laffaire J, Hofman P, Beau-Faller M, Mazieres J, Validire P, Girard P, Camilleri-Bröet S, Vaylet F, Leroy-Ladurie F, Soria JC, Fouret P.

    Clin Cancer Res. 2012 Oct 15;18(20):5606-16.

    doi: 10.1158/1078-0432.CCR-12-0505.  Epub 2012 Aug 22.

    PMID: 22914773

  • Subversion of autophagy in adherent invasive Escherichia coli-infected neutrophils induces inflammation and cell death. PLoS One. 2012;7(12):e51727.

    Chargui A, Cesaro A, Mimouna S, Fareh M, Brest P, Naquet P, Darfeuille-Michaud A, Hébuterne X, Mograbi B, Vouret-Craviari V, Hofman P.

    doi: 10.1371/journal.pone.0051727. Epub 2012 Dec 14.

    PMID: 23272151

  • Etiology of Crohn's disease: many roads lead to autophagy. J Mol Med (Berl). 2012 Sep;90(9):987-96.

    Lapaquette P, Brest P, Hofman P, Darfeuille-Michaud A.

    doi: 10.1007/s00109-012-0934-8. Epub 2012 Jul 14. Review.

    PMID: 22797958

  • Microbes-induced EMT at the crossroad of inflammation and cancer.

    Hofman P, Vouret-Craviari V.

    Gut Microbes. 2012 May-Jun;3(3):176-85.

    doi: 10.4161/gmic.20288. Epub 2012 May 1. Review.

    PMID: 22572828


  • [Setting up indicators in biobanking: why  and how?].

    Hofman V, Gaziello MC, Bonnetaud C, Ilie M, Mauro V, Long E, Selva E, Gavric-Tanga V, Lassalle S, Butori C, Papin-Michaud C, Lerda N, Bordone O, Coelle C, Sabourin JC, Chabannon C, Hofman P.

    Ann Pathol. 2012 Apr;32(2):91-101.

    doi: 10.1016/j.annpat.2012.02.002.  Epub 2012 Mar 28. French.

    PMID: 22520599

  • Expression of a truncated active form of VDAC1 in lung cancer associates with hypoxic cell survival and correlates with progression to chemotherapy resistance.

    Brahimi-Horn MC, Ben-Hail D, Ilie M, Gounon P, Rouleau M, Hofman V, Doyen J, Mari B, Shoshan-Barmatz V, Hofman P, Pouysségur J, Mazure NM.

    Cancer Res.  2012 Apr 15;72(8):2140-50.

    doi: 10.1158/0008-5472.CAN-11-3940. Epub 2012 Mar 2.

    PMID: 22389449

  • Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses.

    Mimouna S, Gonçalvès D, Barnich N, Darfeuille-Michaud A, Hofman P, Vouret-Craviari V.

    Gut Microbes. 2011 Nov-Dec;2(6):335-46.

    doi: 10.4161/gmic.18771. Epub 2011 Nov 1.

    PMID: 22157238

  • Distinct epithelial gene expression phenotypes in childhood respiratory allergy.

    Giovannini-Chami L, Marcet B, Moreilhon C, Chevalier B, Illie MI, Lebrigand K, Robbe-Sermesant K, Bourrier T, Michiels JF, Mari B, Crénesse D, Hofman P, de Blic J, Castillo L, Albertini M, Barbry P.

    Eur Respir J. 2012 May;39(5):1197-205.

    doi: 10.1183/09031936.00070511. Epub 2011 Oct 17.

    PMID: 22005912

  • Predictive clinical outcome of the intratumoral CD66b-positive neutrophil-to-CD8-positive T-cell ratio in patients with resectable nonsmall cell lung cancer.

    Ilie M, Hofman V, Ortholan C, Bonnetaud C, Coëlle C, Mouroux J, Hofman P.

    Cancer. 2012 Mar 15;118(6):1726-37.

    doi: 10.1002/cncr.26456. Epub 2011 Aug 25.

    PMID: 21953630

  • CFTR is involved in the fine tuning of intracellular redox status: physiological implications in cystic fibrosis.

    Duranton C, Rubera I, Cougnon M, Melis N, Chargui A, Mograbi B, Tauc M.

    Am J Pathol. 2012 Oct;181(4):1367-77. doi: 10.1016/j.ajpath.2012.06.017. Epub 2012 Jul 28.

    PMID: 22846720

  • Drug delivery by polymeric nanoparticles induces autophagy in macrophages.

    Eidi H, Joubert O, Némos C, Grandemange S, Mograbi B, Foliguet B, Tournebize J, Maincent P, Le Faou A, Aboukhamis I, Rihn BH.

    Int J Pharm. 2012 Jan 17;422(1-2):495-503. doi: 10.1016/j.ijpharm.2011.11.020. Epub 2011 Nov 22.

    PMID: 22119964

  • Annual Conferences of the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB): overview of 2011 and preview of 2012.

    Chabannon C, Doran P, Hofman P, Seberg O, Cinotti S, Bledsoe M, Deigner HP,  Koschorreck J, Dagher G, Cooreman A, De Blasio P, Riegman P, Hewitt R.

    Biopreserv Biobank. 2012 Oct;10(5):407-15.

    doi: 10.1089/bio.2012.1052.

    PMID: 24845041

  • Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS).

    Ohanna M, Giuliano S, Bonet C, Imbert V, Hofman V, Zangari J, Bille K, Robert C, Bressac-de Paillerets B, Hofman P, Rocchi S, Peyron JF, Lacour JP, Ballotti R, Bertolotto C.

    Genes Dev. 2011 Jun 15;25(12):1245-61.

    doi: 10.1101/gad.625811. Epub 2011 Jun 6.

    PMID: 21646373


  • Risk predisposition for Crohn disease: a "ménage à trois" combining IRGM allele, miRNA and xenophagy.

    Brest P, Lapaquette P, Mograbi B, Darfeuille-Michaud A, Hofman P.

    Autophagy. 2011 Jul;7(7):786-7. Epub 2011 Jul 1.

    PMID: 21508684

  • Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung  carcinoma: comparison of the efficacy of the CellSearch Assay™ and the isolation  by size of epithelial tumor cell method.

    Hofman V, Ilie MI, Long E, Selva E, Bonnetaud C, Molina T, Vénissac N, Mouroux J, Vielh P, Hofman P.

    Int J Cancer. 2011 Oct 1;129(7):1651-60.

    doi: 10.1002/ijc.25819. Epub 2011 Mar 11.

    PMID: 21128227.

  • Gene expression signature discriminates sporadic from post-radiotherapy-induced thyroid tumors.

    Ory C, Ugolin N, Levalois C, Lacroix L, Caillou B, Bidart JM, Schlumberger M, Diallo I, de Vathaire F, Hofman P, Santini J, Malfoy B, Chevillard S.

    Endocr Relat Cancer. 2011 Jan 19;18(1):193-206.

    doi: 10.1677/ERC-10-0205. Print 2011 Feb.

    PMID: 21148326

  • Cytopathologic detection of circulating tumor cells using the isolation by size of epithelial tumor cell method: promises and pitfalls.

    Hofman VJ, Ilie MI, Bonnetaud C, Selva E, Long E, Molina T, Vignaud JM, Fléjou JF, Lantuejoul S, Piaton E, Butori C, Mourad N, Poudenx M, Bahadoran P, Sibon S, Guevara N, Santini J, Vénissac N, Mouroux J, Vielh P, Hofman PM.

    Am J Clin Pathol. 2011 Jan;135(1):146-56.

    doi: 10.1309/AJCP9X8OZBEIQVVI.

    PMID: 21173137.

  • Discriminating gene expression signature of radiation-induced thyroid tumors after either external exposure or internal contamination.

    Ory C, Ugolin N, Schlumberger M, Hofman P, Chevillard S.

    Genes (Basel). 2011 Dec 21;3(1):19-34.

    doi: 10.3390/genes3010019.

    PMID: 24704841

  • A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease.

    Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hébuterne X, Harel-Bellan A, Mograbi B, Darfeuille-Michaud A, Hofman P.

    Nat Genet. 2011 Mar;43(3):242-5.

    doi: 10.1038/ng.762. Epub 2011 Jan 30. 

    PMID: 21278745

  • Cadmium-induced autophagy in rat kidney: an early biomarker of subtoxic exposure.

    Chargui A, Zekri S, Jacquillet G, Rubera I, Ilie M, Belaid A, Duranton C, Tauc M, Hofman P, Poujeol P, El May MV, Mograbi B.

    Toxicol Sci. 2011 May;121(1):31-42.

    doi: 10.1093/toxsci/kfr031. Epub 2011 Feb 15.

    PMID: 21325019

  • Clinical impact of cervical lymph node involvement and central neck dissection in patients with papillary thyroid carcinoma: a retrospective analysis of 368 cases.

    Bozec A, Dassonville O, Chamorey E, Poissonnet G, Sudaka A, Peyrottes I, Ettore F, Haudebourg J, Bussière F, Benisvy D, Marcy PY, Sadoul JL, Hofman P, Lassale S, Vallicioni J, Demard F, Santini J.

    Eur Arch Otorhinolaryngol. 2011 Aug;268(8):1205-1212.

    doi: 10.1007/s00405-011-1639-2. Epub 2011 May 24.

    PMID: 21607578

  • miR-483-3p controls proliferation in wounded epithelial cells.

    Bertero T, Gastaldi C, Bourget-Ponzio I, Imbert V, Loubat A, Selva E, Busca  R, Mari B, Hofman P, Barbry P, Meneguzzi G, Ponzio G, Rezzonico R.

    FASEB J. 2011 Sep;25(9):3092-105.

    doi: 10.1096/fj.10-168401. Epub 2011 Jun 15.

    PMID: 21676945

  • The role of a bioresource research impact factor as an incentive to share human bioresources.

    Cambon-Thomsen A, Thorisson GA, Mabile L; BRIF Workshop Group.

    Nat Genet. 2011 Jun;43(6):503-4.

    doi: 10.1038/ng.831.

    PMID: 21614086

  • MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells.

    Brest P, Lassalle S, Hofman V, Bordone O, Gavric Tanga V, Bonnetaud C, Moreilhon C, Rios G, Santini J, Barbry P, Svanborg C, Mograbi B, Mari B, Hofman P.

    Endocr Relat Cancer. 2011 Nov 14;18(6):711-9.

    doi: 10.1530/ERC-10-0257. Print 2011 Dec.

    PMID: 21946411

  • Strategy to find molecular signatures in a small series of rare cancers: validation for radiation-induced breast and thyroid tumors.

    Ugolin N, Ory C, Lefevre E, Benhabiles N, Hofman P, Schlumberger M, Chevillard S.

    PLoS One. 2011;6(8):e23581.

    doi: 10.1371/journal.pone.0023581. Epub 2011 Aug 11.

    PMID: 21853153

  • Can the microRNA signature distinguish between thyroid tumors of uncertain malignant potential and other well-differentiated tumors of the thyroid gland?

    Lassalle S, Hofman V, Ilie M, Bonnetaud C, Puisségur MP, Brest P, Loubatier  C, Guevara N, Bordone O, Cardinaud B, Lebrigand K, Rios G, Santini J, Franc B, Mari B, Al Ghuzlan A, Vielh P, Barbry P, Hofman P.

    Endocr Relat Cancer. 2011 Sep 13;18(5):579-94.

    doi: 10.1530/ERC-10-0283. Print 2011 Oct.

    PMID: 21778212

  • The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway.

    Tauzin S, Chaigne-Delalande B, Selva E, Khadra N, Daburon S, Contin-Bordes C, Blanco P, Le Seyec J, Ducret T, Counillon L, Moreau JF, Hofman P, Vacher P, Legembre P.

    PLoS Biol. 2011 Jun;9(6):e1001090.

    doi: 10.1371/journal.pbio.1001090. Epub 2011 Jun 21.

    PMID: 21713032

  • The endoplasmic reticulum stress response chaperone: Gp96, a host receptor for Crohn disease-associated adherent-invasive Escherichia coli.

    Rolhion N, Hofman P, Darfeuille-Michaud A.

    Gut Microbes. 2011 Mar-Apr;2(2):115-9. Epub 2011 Mar 1. Review.

    PMID: 21637029

  • Circulating tumor cells in prostate cancer: a potential surrogate marker of survival.

    Doyen J, Alix-Panabières C, Hofman P, Parks SK, Chamorey E, Naman H, Hannoun-Lévi JM.

    Crit Rev Oncol Hematol. 2012 Mar;81(3):241-56.

    doi: 10.1016/j.critrevonc.2011.05.004. Epub 2011 Jun 15. Review.

    PMID: 21680196

  • Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and Crohn's disease patients.

    Denizot J, Sivignon A, Barreau F, Darcha C, Chan HF, Stanners CP, Hofman P,  Darfeuille-Michaud A, Barnich N.

    Inflamm Bowel Dis. 2012 Feb;18(2):294-304.

    doi: 10.1002/ibd.21787. Epub 2011 Jun 17.

    PMID: 21688348

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