Institute for Research on Cancer and Aging, Nice
Institute for Research on Cancer and Aging, Nice
Institute for Research on Cancer and Aging, Nice
Institute for Research on Cancer and Aging, Nice
Institute for Research on Cancer and Aging, Nice
Highlights & Outreach
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News : Publication "How "jumping genes" travel between species".
Interview with Gaël Cristofari for Le M
Featured research
Stress Response and Oncogenesis
Dmitry BULAVIN, Research Director, DR1 Inserm
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Retrotransposons and genome plasticity
Gael CRISTOFARI, Research Director, DR2 Inserm
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Tumor-Stroma Crosstalk in Invasive Cancer
Cedric GAGGIOLI, Research Director, DR2 Inserm
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Epithelial homeostasis and tumorigenesis
Chloé FÉRAL, Research Director, DR2 Inserm
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Telomere Shortening in Cancer and Aging
Miguel GODINHO FERREIRA, Research Director, DR2 CNRS
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Carcinogenesis-related chronic active inflammation
Paul HOFMAN, Professor-Clinician, PU-PHCE
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Telomere, senescence and cancer
Eric GILSON, Director, Professor-Clinician, PU-PHCE
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Population genomics and complex traits
Gianni LITI, Research Director, DR1 CNRS
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Normal and pathological angiogenesis
Gilles PAGÈS, Research Director, DR1 Inserm
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Genetics of solid tumors
Florence PEDEUTOUR, Professor-Clinician, PU-PH1
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Genetics of mitochondrial diseases
Véronique PAQUIS-FLUCKLINGER, Professor-Clinician, PU-PHCE
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Stress Response, regeneration & longevity
Eric RÖTTINGER, Research Director, DR2 CNRS
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Transcription Specificity
Simona SACCANI, Research Director, DR2 Inserm
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Telomerase and adult stem cell homeostasis
Marina SHKRELI, Researcher, CRCN Inserm
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Molecular Hematology - Blood signals
Eirini TROMPOUKI, Research Director, DR2 Inserm
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Latest publications
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Different environmental response strategies in sympatric corals from Pacific Islands
Porro B, Zamoum T, Forcioli D, Gilson E, Poquet A, Di Franco E, Barnay-Verdier S, Lombard F, Voolstra CR, Hume BCC, Galand PE, Moulin C, Boissin E, Bourdin G, Iwankow G, Poulain J, Sarah Romac S, Agostini S, Banaigs B, Emmanuel Boss 14, Chris Bowler 8,18, Colomban de Vargas16, Eric Douville E, Flores M, Pesant S, Reynaud S, Sullivan MB, Sunagawa S, Thomas OP, Troublé R, Vega Thurber R, Wincker P, Zoccola D, Planes S, Allemand D, Röttinger E & Furla P
Communications Earth & Environment 4:311
PMID: cee
Telomere-to-telomere assemblies of 142 strains characterize the genome structural landscape in Saccharomyces cerevisiae
O'Donnell S*, Yue JX*, Saada OA, Agier N, Caradec C, Cokelaer T, De Chiara M, Delmas S, Dutreux F, Fournier T, Friedrich A, Kornobis E, Li J, Miao Z, Tattini L, Schacherer J@, Liti G@, Fischer G@.Nature Genetics. 2023 Jul 31.
doi: 10.1038/s41588-023-01459-y.
PMID: 37524789
Disparate genetic divergence patterns in three corals across a pan-Pacific environmental gradient highlight species-specific adaptation
Christian R. Voolstra, Benjamin C. C. Hume, Eric J. Armstrong, Guinther Mitushasi, Barbara Porro, Nicolas Oury, Sylvain Agostini, Emilie Boissin, Julie Poulain, Quentin Carradec, David A. Paz-García, Didier Zoccola, Hélène Magalon, Clémentine Moulin, Guillaume Bourdin, Guillaume Iwankow, Sarah Romac, Bernard Banaigs, Emmanuel Boss, Chris Bowler, Colomban de Vargas, Eric Douville, Michel Flores, Paola Furla, Pierre E. Galand, Eric Gilson, Fabien Lombard, Stéphane Pesant, Stéphanie Reynaud, Matthew B. Sullivan, Shinichi Sunagawa, Olivier P. Thomas, Romain Troublé, Rebecca Vega Thurber, Patrick Wincker, Serge Planes, Denis Allemand & Didier Forcioli
npj Biodiversity, 2, 15 (2023)
PMID: npj Biodiversity
N-terminal alanine-rich (NTAR) sequences drive precise start codon selection resulting in elevated translation of multiple proteins including ERK1/2.
Initiation of translation is essential for protein synthesis. A crucial step is the correct choice of the start AUG, which leads to the production of the fully functional polypeptide. To date, nucleotide composition next to the AUG has been considered the only determinant of start codon selection. Our work identifies a large family of proteins whose start codon choice is determined by an N-terminal alanine-rich sequence (NTAR) that enables efficient protein translation. Many of these proteins are encoded by housekeeping genes. Among them, the NTARs of the pivotal kinases ERK1 and ERK2 are highly optimized in humans, shaping ERK signal...
Telomere DNA length regulation is influenced by seasonal temperatures differences in short-lived but not in long- lived reef-building corals
Rouan A, Pousse M, Djerbi N, Porro B, Bourdin G, Carradec Q, Hume BCC, Poulain J,Le-Hoang J, Armstrong E, Agostini S, Die Morini L, Leone C, Wurzer L, Tran J, McMinds R, A. Paz-García D, Giraud-Panis MJ, Deshuraud R, Ottaviani A, Zoccola D, Pey A, Moulin C, Boissin E, Iwankow G, Poulain J, Romac S, Tara Pacific Consortium Coordinators, Planes S, Allemand D, Pesant S, Wincker P, Röttinger E, Furla P, Voolstra CR, Forcioli D, Lombard F and Gilson E
Nature Communications, 1;14(1):3038
PMID: 37263999
Telomere DNA length regulation is influenced by seasonal temperature differences in short-lived but not in long-lived reef-building corals
Rouan A, Pousse M, Djerbi N, Porro B, Bourdin G, Carradec Q, Hume BCC, Poulain J,Le-Hoang J, Armstrong E, Agostini S, Die Morini L, Leone C, Wurzer L, Tran J, McMinds R, A. Paz-García D, Giraud-Panis MJ, Deshuraud R, Ottaviani A, Zoccola D, Pey A, Moulin C, Boissin E, Iwankow G, Poulain J, Romac S, Tara Pacific Consortium Coordinators, Planes S, Allemand D, Pesant S, Wincker P, Röttinger E, Furla P, Voolstra CR, Forcioli D, Lombard F and Gilson E
Nature Communications, 1;14(1):3038
PMID: 37263999
Open science resources from the Tara Pacific expedition across coral reef and surface ocean ecosystems
Lombard F, Bourdin G, Pesant S, Agostini S, Baudena A, Boissin E, Cassar N, Clampitt M, Conan P, Da Silva O, Dimier C, Douville E, Elineau A, Fin J, Flores M, Ghiglione J, Hume B, Jalabert L, John S, Kelly R, Koren I, Lin Y, Marie D, McMinds R, Mériguet Z, Metzl N, Paz-García D, Pedrotti M, Poulain J, Pujo-Pay M, Ras J, Reverdin G, Romac S, Rouan A, Röttinger E, Vardi A, Voolstra C, Moulin C, Iwankow G, Banaigs B, Bowler C, de Vargas C, Forcioli D, Furla P, Galand P, Gilson E, Reynaud S, Sunagawa S, Sullivan M,...
Embracing the diversity of model systems to deconstruct the basis of regeneration and tissue repair
Amiel AR, Tsai SL, Wehner D.
Development, 150 (3): dev201579
PMID: 36718794
The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging.
Ying Y, Hu X, Han P, Mendez-Bermudez A, Bauwens S, Eid R, Tan L, Pousse M, Giraud-Panis MJ, Lu Y, Gilson E, Ye J.
Nucleic Acids Res. 2022 Feb 28;50(4):2081-2095. doi: 10.1093/nar/gkac065. PMID: 35150283
Telomeres as a sentinel of population decline in the context of global warming.
Lemaître JF, Gaillard JM, Gilson E. Proc Natl Acad Sci U S A.
2022 Aug 30;119(35):e2211349119. doi: 10.1073/pnas.2211349119. Epub 2022 Aug 10. PMID: 35947638
Loss of atm in Zebrafish as a Model of Ataxia-Telangiectasia Syndrome.
Chen K, Wang P, Chen J, Ying Y, Chen Y, Gilson E, Lu Y, Ye J.
Biomedicines. 2022 Feb 7;10(2):392. doi: 10.3390/biomedicines10020392. PMID: 35203601
Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence.
Mendez-Bermudez A, Lototska L, Pousse M, Tessier F, Croce O, Latrick CM, Cherdyntseva V, Nassour J, Xiaohua J, Lu Y, Abbadie C, Gagos S, Ye J, Gilson
Nucleic Acids Res. 2022 Jul 22;50(13):7493-7510. doi: 10.1093/nar/gkac603. PMID: 35819196