Thesis directors: Dr Chloé FERAL (IRCAN) & Dr. Christophe HENRY (Sanofi) Please note that a short confidentiality form will need to be signed before the defense. Abstract: Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths globally and in France, largely due to late-stage diagnosis and the ineffectiveness of conventional treatments. Although […]
Thesis Director: Dr Eirini TROMPOUKI Abstract: Hematopoietic stem cells (HSCs) sustain lifelong blood and immune cell production by balancing self-renewal and differentiation. Aging of HSCs is characterized by an expansion of phenotypic HSCs in the bone marrow, activation of myeloid-biased transcriptional programs, accumulation of DNA damage and epigenetic alterations, and disruption of proteostasis, particularly pathways […]
"Communication cellule-matrice extracellulaire : un facteur clé dans la différenciation et la transformation des progéniteurs pulmonaires " Abstract : My research work aims to better understand the mechanisms that link lung regeneration and tumorigenesis, particularly in lung adenocarcinoma (LUAD). The lung is organized into distinct anatomical compartments, including the bronchioles and alveoli, which host specific populations of progenitor […]
Eric GILSON invites: Oliver BISCHOF, Institut Mondor de Recherche Biomédicale, Créteil "Cellular Senescence: A Context-Dependent Program in Health, Aging, and Disease"
Eric GILSON invites: Anabelle DECOTTIGNIES - Duve Institute, Brussels "The unexpected lipid connection of telomeres"
"Telomere Control of Genome Replication and Stability: From Heterochromatin to Mitochondria"
Gianni LITI invites: Pr Patrick CAI - PC, Manchester "Engineering and Safeguarding Synthetic Genomes" Abstract: Over the last 12 years, my lab has been building synthetic yeast chromosomes from scratch. These synthetic genomes are engineered to allow genome-wide directed evolution with a system call SCRaMbLE (Synthetic Chromosome Recombination and Modification by LoxP-Mediated Evolution). […]
Simona SACCANI invites: Sestina FALCONE - Sorbonne Université UMRS974-Inserm-Institut de Myologie "Identification of CaVβ1 subunits and their role in the neuromuscular system from embryo to aging" Abstract: Voltage-gated Ca2+ channels (VGCCs) are regulated by four CaVβ subunits (CaVβ1-CaVβ4), each showing specific expression patterns in excitable cells. While primarily known for regulating VGCC function, CaVβ […]
Jae LI - Senior product manager in BGI tech solutions, spatial omics service line responsible "Stereo-seq: Spatial Transcriptomics Solution" Abstract: In this technical seminar, we will introduce BGI's cutting-edge spatial transcriptomics technology — Stereo-seq, and comprehensive spatial analysis solutions compatible with both FF (Fresh Frozen) and FFPE (Formalin-Fixed, Paraffin-Embedded) samples. Featuring nanoscale subcellular resolution […]
Eric GILSON invites: Eric BAPTESTE - Department of Computational and Quantitative Biology, UMR 7238 Sorbonne Université-CNRS " Gaps in the Explanations of Aging: An Evolutionary Perspective" Abstract: The causes of aging are numerous and not yet fully understood. Theories intended to explain the evolution of aging also contain certain gray areas. In […]
Gianni LITI invites : Jia-Xing Yue - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China "Telomere variation and inheritance at individual and population scales" Abstract: Telomeres are specialized repetitive DNA sequences located at the termini of eukaryotic nuclear chromosomes, protecting them […]