External seminar: Keisuke ITO

Eirini TROMPOUKI invites: Keisuke ITO

Albert Einstein College of Medicine, Director of Scientific Resources, The Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine, USA

« Mitochondrial metabolism shaping hematopoietic stem cell fate and its therapeutic targeting in hematological disorders« 

Abstract: Hematopoietic stem cells (HSCs) rely on precisely coordinated metabolic programs to preserve function, adapt to environmental cues, and sustain lifelong hematopoiesis. Mitochondria play a crucial role in supporting diverse metabolic pathways to meet cellular energy demands; however, the mechanisms by which mitochondrial metabolism shapes HSC fate remain elusive. At the Ito Laboratory, we aim to elucidate the regulatory networks governing healthy and malignant HSCs. For example, we have explored how mitochondrial quality control and lipid metabolism shape HSC homeostasis, the roles of extracellular vesicles in maintaining HSC properties, and, more recently, initiated projects targeting mitochondria for therapy in acute myeloid leukemia. In this presentation, I will summarize our progress in understanding how mitochondria and cellular metabolism influence HSC fate. Deeper insights into metabolic regulation will refine HSC transplantation and drive novel therapies for hematologic disorders and malignancies