Current lab members:
- Simona SACCANI, Research Director, DR2 Inserm
- D. van Essen (CRCN)
- O. Bellouti (PhD student)
- S. Damodaran (PhD student)
- L. Cervera (Engineer)
Lab Alumni:
The Saccani lab studies the molecular mechanisms which regulate gene expression, using the NF-kB family of transcription factors as a model system. A major focus is to understand how the activities of transcription factors can be controlled in promoter-specific and cell type-specific fashion. The NF-kB family of transcription factors is crucial for the expression of multiple genes involved in cell survival, proliferation, differentiation and inflammation. The NF-kB pathway is broadly active in multiple cell types, yet many NF-kB target genes show a tightly-regulated pattern of expression, with stimulus-dependent activation restricted to a particular biological setting. To investigate the molecular mechanisms underlying this, we focus on differences in the chromatin structure of target promoters and enhancers, and on co-factors which can regulate the recruitment and activity of NF-kB in specific cell-types.
Current Projects
Publications
Lab News
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Fête de la Science 2024
IRCAN was once again present at the Village des Sciences de Nice on October 11, 12 and 13 to talk about our research with: – middle and high school students […]
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New Website!
Please enjoy our new website! We want to create a imersive hub for all news and events in the fields of cancer and ageing. if you see an error, please […]
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IRCAN has a diverse research teams, tackling a wide range and resolution of topics in ageing and cancer.