Current lab members:
- Dr Gaggioli Cédric, DR2 INSERM
- Dr Lopez Pascal, CRCN INSERM
- Miss Artieres Lydia (PhD)
- Dr Albrengues Jean, CRCN INSERM
- Miss Mousset Alexandra (Ph D)
- Dr Bourget Isabelle, IE INSERM
- Mr. Odet Quentin (IE, CDD) (3D-Hub-S platform)
Lab Alumni:
In primary tumors, cancer cells are immersed in a complex microenvironment network comprising numerous cells, including carcinoma associated fibroblasts (CAF). Tumor-stroma crosstalk plays a major role in carcinoma development and invasion. We have previously demonstrated the crucial role of Janus Kinase dependent signalling pathway, in CAF cells, for matrix remodelling and tracks formation for cancer cells to invade. However, how “normal” resident fibroblasts are converted into pro-invasive CAF cells remains an open question. Malignant cells themselves promotes carcinogenesis through cytokines and growth factors secretion that influence stroma cells behaviour, which in return influence carcinoma cells invasion and malignancy. In line with our previous research, we aim at uncovered signalling pathways and molecules that govern stromal fibroblasts and carcinoma cells crosstalk during invasion, which could lead to the identification of therapeutic target for aggressive and metastatic cancer.
Current Projects
Top Publications
Lab News
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Double Recognition for IRCAN: ANTIAGE Platform Receives IBiSA Accreditation, and 3D-Hub-S is Reaccredited
We are delighted to share two major accomplishments for IRCAN’s research platforms: ANTIAGE Platform: Innovation in Aging Research The ANTIAGE platform is dedicated to studying the fundamental mechanisms of stress […]
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Fête de la Science 2024
IRCAN was once again present at the Village des Sciences de Nice on October 11, 12 and 13 to talk about our research with: – middle and high school students […]
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New Website!
Please enjoy our new website! We want to create a imersive hub for all news and events in the fields of cancer and ageing. if you see an error, please […]
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IRCAN has a diverse research teams, tackling a wide range and resolution of topics in ageing and cancer.