Current lab members:
- Miguel Godinho FERREIRA (DR2 CNRS)
- Giulia Allavena (MSCA Post-Doc)
- Andreia Marques (PhD Student)
- Ana Cano (MSc students and IE)
Lab Alumni:
Our main goal is to understand the mechanisms that promote the rise of cancer incidence with age and to understand the role telomeres plays on this phenomenon. We have developed novel vertebrate system to study this question – the zebrafish. Contrary to common mouse models, zebrafish has natural shorter telomeres that decline with age and limit cell proliferation and longevity.
Telomeres protect the ends of chromosomes from inappropriately being recognized as a double strand break and constant DNA erosion. As telomeres shorten throughout life, we lose this protection, leading to cell senescence and, possibly, genome instability.
We are testing an hypothesis that attempts to explain the apparent paradox of cancer arising at this stage of low cell proliferation. Due to telomere shortening, senescent cells accumulate with age. These cells secrete a very distinct set of signaling factors, proteases and other molecules (SASP). SASP promotes both malignant phenotypes in culture and tumor growth and invasiveness in vivo. The “seed-and-soil” theory proposes the importance of the microenvironment for carcinogenesis. With aging, senescent cells with short telomeres may provide the right soil for tumors to arise in a non-cell autonomous manner.
Current Projects
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Decipher molecular mechanisms responsible for mitochondrial dysfunction leading to motor neuron death
Decipher molecular mechanisms responsible for mitochondrial dysfunction leading to motor neuron death. 2022-2025, FRM-Maladies neurodégénératives, PI Véronique Paquis-Flucklinger The project aims to understand the molecular basis of motor neuron death […]
Top Publications
Lab News
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New Website!
Please enjoy our new website! We want to create a imersive hub for all news and events in the fields of cancer and ageing. if you see an error, please […]
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The Connection – Interview
Earlier this month, English written french newsaper, The Connection, interviwed our Director Dmitry Bulavin about IRCAN. Read the full article here; https://www.connexionfrance.com/practical/french-state-scientists-want-to-help-people-live-to-120-in-good-health/657210
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EMBO Workshop 9-12 April 2024
The IRCAN Institute is excited to partner with EMBO for an workshop titled ‘Developmental Circuits in Aging.’ organised by Eric Gilson. About the Workshop The proposed EMBO Workshop aims at presenting […]
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IRCAN has a diverse research teams, tackling a wide range and resolution of topics in ageing and cancer.