Current lab members:
- Eric GILSON PU-PH
- Marie-Josèphe GIRAUD-PANIS, DR2 CNRS
- Delphine BENARROCH, CRCN Inserm
- Alexandre OTTAVIANI, MCU
- Aaron MENDEZ BERMUDEZ IR Inserm
- Serge BAUWENS, IR CNRS
- Sabrina PISANO, IR Inserm
- Florentin REMOT Post-Doc CNRS
- Huong LAI, PhD
- Peipei LIN, PhD
- Romane DESHURAUD, PhD
- Rita HILMA CDD IR CNRS
- Nadir DJERBI, AI CNRS
- Francesco ABAGNALE CDD AI Inserm
- Juliette QUEGUINER CDD IE Inserm
- Irena DELGADO, Master
- Hongly RUAN, Master
Lab Alumni:
The objective of the research in Eric Gilson team is to provide further mechanisms and molecular tools that describe telomeres as nuclear integrated structures and to understand how cell fate is determined by telomere changes with application in the aging and medical fields.
Historically, the general strategy of the team is a bottom-up approach starting from the key shelterin component TRF2, addressing numerous aspects of its structure and function relationships by combining biophysical, biochemical, molecular, cellular, genetic, experimental oncogenesis and clinical studies. The team aims at applying the knowledge gained from their research on TRF2 to address general questions regarding telomere protection and signaling, replicative senescence, immunosurveillance, organismal aging and oncogenesis as well to the development of novel clinical approaches to treat cancer and to prevent age-associated pathologies.
Recently, the team decided to address the question of the relationships between telomere and aging from a different angle by asking the basic question: does evolution change the life history of species by modifying telomere biology? This is currently addressed by studying the link between telomere variation and organismal fitness using natural populations of both budding yeast (in collaboration with the Gianni Liti team) and reef-building coral, taking advantage of the current TARA-PACIFIC expedition that is sampling corals throughout the Pacific over a 2-years cruise.
Current Projects
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InterAgeing
Duration: 2021-2026 Funding body: INSERM The InterAging project, initiated by Inserm, aims to enhance research into aging through international collaboration. Launched in October 2021, this project seeks to combine insights […]
Top Publications
Lab News
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Fête de la Science 2024
IRCAN was once again present at the Village des Sciences de Nice on October 11, 12 and 13 to talk about our research with: – middle and high school students […]
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New Website!
Please enjoy our new website! We want to create a imersive hub for all news and events in the fields of cancer and ageing. if you see an error, please […]
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EMBO Workshop 9-12 April 2024
The IRCAN Institute is excited to partner with EMBO for an workshop titled ‘Developmental Circuits in Aging.’ organised by Eric Gilson. About the Workshop The proposed EMBO Workshop aims at presenting […]
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IRCAN has a diverse research teams, tackling a wide range and resolution of topics in ageing and cancer.