Interview with Gaël Cristofari for Le Monde - Science & Médecine

 PMID: 37414542 DOI: 10.1093/nar/gkad528 Initiation of translation is essential for protein synthesis. A crucial step is the correct choice of the start AUG, which leads to the production of the fully functional polypeptide. To date, nucleotide composition next to the AUG has been considered the only determinant of start codon selection. Our work identifies a large family of proteins whose start codon choice is determined by an N-terminal alanine-rich sequence (NTAR) that enables efficient protein translation. Many of these proteins are encoded by housekeeping genes. Among them, the NTARs of the pivotal kinases ERK1 and ERK2 are highly optimized in humans, shaping ERK signal transduction by increasing the kinase quantity. Our findings could be useful for applied biology, especially for mRNA-based therapeutics. https://doi.org/10.1093/nar/gkad528 https-pubmed-ncbi-nlm-nih-gov-37414542    

Gaël Cristofari received the "coup de coeur" award in the editorial communications category of the ARCES Prize: "InScience" comic striphttps://www.calameo.com/read/0051544509cf52b7059c6 (Genetic tourism: genes on the move - page 18)Congratulations!