Sunitinib Stimulates Expression of VEGFC by Tumor Cells and Promotes Lymphangiogenesis in Clear Cell Renal Cell Carcinomas.
Dufies M, Giuliano S, Ambrosetti D, Claren A, Ndiaye PD, Mastri M, Moghrabi W, Cooley LS, Ettaiche M, Chamorey E, Parola J, Vial V, Lupu-Plesu M, Bernhard JC, Ravaud A, Borchiellini D, Ferrero JM, Bikfalvi A, Ebos JM, Khabar KS, Grépin R, Pagès G.
Cancer Res. 2017, Jan 13.
The ground for lung tumours : how does it operate and how to get rid of ?
Dmitry Bulavin, winner of the call for projects « Leaders of tomorrow in Oncology » in 2012, has published with his team the results of their work about the first steps of lung cancer development.
The future prospects, very concrete, are exciting.
* Brichkina A, Bertero T, Loh HM, Nguyen NT, Emelyanov A, Rigade S, Ilie M, Hofman P, Gaggioli C, Bulavin DV.
p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis.
Genes Dev. 2016 Dec 1;30(23):2623-2636.
“Powerful decomposition of complex traits in a diploid model” published in Nature Communications on 2nd November 2016 (www.ncbi.nlm.nih.gov/pubmed/?term=gianni+Liti+Nature+Communications) by Johan Hallin, Kaspar Martens, Alexander I.Young, Martin Zackrisson, Francisco Salinas, Leopold Parts, Jonas Warringer, Gianni Liti
Maeva DUFIES, post-doc in Dr Gilles Pagès' team, received a distinction of 10 000 Euros of the Groupe Pasteur Mutualité for her research project : "Rôle du facteur VEGFC dans les propriétés métastatiques acquises en réponse aux traitements anti-angiogéniques dans le cancer du rein".
May 2016 :
Pr Emmanuel Van Obberghen received the Paul Langerhans award.
This is the most important award granted by the German Diabetes Society.
May 2016 : Pr Eric Gilsons’ team is coordinating the “stress/télomère” study of the next TARA-PACIFIC expedition
The scientific schonner Tara will leave its home port in Lorient, France, on May 28th, 2016, for a new scientific expedition in the asian and pacific area.
It will cross the pacific ocean over almost 100 000 km during more than 2 years with a interdisciplinary scientific team on its board, coordinated by the CNRS and the Scientific Centre of Monaco (CSM). Their aim is to study in an unprecedented way the coral reefs biodiversity and their evolution facing the climat change and the anthropogenic pressures. This adventure is sponsored by the CNRS, PSL, CEA, CSM and many other private and publics sponsors.
Pr Eric Gilson's Team published in Jan. 2016, in Molecular Cell a pertinent study entitled: TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
Authors : Benarroch-Popivker D*, Pisano S*, Mendez-Bermudez A, Lototska L, Kaur P, Bauwens S, Djerbi N, Latrick CM, Fraisier V, Pei B, Gay A, Jaune E, Foucher K, Cherfils-Vicini J, Aeby E, Miron S, Londoño-Vallejo A, Ye J, Le Du MH, Wang H, Gilson E, Giraud-Panis MJ.
The Inserm magazine, “Science et Santé” published a report on this work (http://editions.inserm.fr/Science_Sant%C3%A9%20(MARS-AVRIL%202016)#p=9).
Dr Sabrina Pisano, at the 7th AFM BioMed conference (Porto, April 2016), and Dr Delphine Benarroch-Popivker, at the Telomere Embo meeting (Belgium, May 2016) were awarded the “best poster presentation” for this work.
Mrs Estelle LECOINTE, President of the INFOSARCOMES patient association, will come to visit the IRCAN on Friday April 29th, 2016. Pr Florence Pedeutour will welcome the President and some patients at 13.30 and after a presentation in Room ED8 will make them visit the laboratory.
A MAJOR STEP FORWARD IN PERSONALIZED MEDICINE
The team of Professor Pedeutour, Team leader at the IRCAN and Responsable of the Hospital Laboratory of Genetics of solid tumors, has published in The Lancet Oncology "Clinical effect of molecular methods in sarcoma diagnosis (GENSARC): a prospective, multicentre, observational study" - http://www.ncbi.nlm.nih.gov/pubmed/26970672). March 2016.
Dr Gaël CRISTOFARI 's team has published a new relevant study entitled "Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci" in eLife, March 2016 : http://elifesciences.org/content/5/e13926v1
Dr Gilles PAGÈS, team leader at the IRCAN, is the new President of the French Asssociation for Angiogenesis : http://www.angiogenese.fr/ (March 2016)
The regional newspaper "Nice-Matin" published on October 10th, 2015 - "Rares Cancers : patients, researchers, hand in hand". The team of Professor Florence Pedeutour is starting a promising study on sarcomas, sponsored by the "Info-Sarcomes Association".
On June 25th, 2015, during the annual meeting of the French Sarcoma Group in Bordeaux, Laurence Bianchini and Florence Pedeutour received a price from the "Info-Sarcomes Association" (President Mrs Estelle Lecointe) for their research project : "La voie de signalisation cellulaire FGF/FGFR : une nouvelle cible thérapeutique dans les liposarcomes dédifférencés". All informations are available on http://www.infosarcomes.org/projets-de-lannee-2015.
* The french magazine "La Recherche" published in June 2015 a report on young scientists "under 40 and representing the scientific future of the french research" (La Recherche, N° 500, Juin 2015). Among these scientists, Gaël Cristofari, Team leader at the IRCAN Institute, was cited.
* Mrs Marilena Lupu-Plesu, Marie-Curie Fellow in the team of Gilles Pagès, is in charge of the FP7 Marie-Curie VELYMPH project from the European Commission :
“Investigation of VEGF-C involvement in the acquired metastatic properties of renal cell carcinoma following anti-angiogenesis treatments”
(Jan 2015 - Dec 2016). More details
* Pr Paul Hofman's Team published in Plos One (Oct 31st, 2014) an new technique permitting early diagnosis of lung cancer :
"Sentinel circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease".
Authors : M Ilie, V Hofman, E Long-Mira, E Selva, JM Vignaud, B Padovani, J Mouroux, CH Marquette, P Hofman.
* Pr Eric Gilson's Team published on Oct 23rd, 2014, in Cell Reports an outstanding
"The telomeric protein TRF2 regulates angiogenesis by binding and activating the PDGFR-beta promoter".
Authors : M El Maï, K-D Wagner, J-F Michiels, D Ambrosetti, A Borderie, S Destree, V Renault, N Djerbi, M-J Giraud-Panis, E Gilson, N Wagner.
DISTINCTIONS & PHD THESIS Price
* June 4th, 2015. DuPont Awards Early Career Grants to Nine Promising University
Research Leaders : Gianni Liti, Chargé de Recherche CNRS and Team Leader at the
IRCAN received the "Dupont Young Professor Award" More Details
Amine Belaid, from the IRCAN Paul Hofman's team, received a price from the PhD Student School of the Nice University for the best thesis realized in 2013. Title : "SQSTM1, une plateforme de signalisation clé contrôlant l'autophagie sélective jusqu'à la reprogrammation tumorale", Director of the thesis : Dr Baharia Mograbi.
Nice, September 2014